PMID: 9159397May 1, 1997Paper

Dynamic, mitotic-like behavior of a bacterial protein required for accurate chromosome partitioning

Genes & Development
P GlaserJ Errington

Abstract

The Bacillus subtilis spo0J gene is required for accurate chromosome partitioning during growth and sporulation. We have characterized the subcellular localization of Spo0J protein by immunofluorescence and, in living cells, by use of a spo0J-gfp fusion. We show that the Spo0J protein forms discrete stable foci usually located close to the cell poles. The foci replicate in concert with the initiation of new rounds of DNA replication, after which the daughter foci migrate apart inside the cell. This migration is independent of cell length extension, and presumably serves to direct the daughter chromosomes toward opposite poles of the cell, ready for division. During sporulation, the foci move to the extreme poles of the cell, where they function to position the oriC region of the chromosome ready for polar septation. These observations provide strong evidence for the existence of a dynamic, mitotic-like apparatus responsible for chromosome partitioning in bacteria.

References

Oct 25, 1979·Journal of Molecular Biology·T McGinness, R G Wake
Mar 1, 1992·Molecular Microbiology·N Ogasawara, H Yoshikawa
Jan 1, 1992·Journal of General Microbiology·D R Williams, C M Thomas
Jan 1, 1990·Journal of Bacteriology·S HiragaH Mori
Jul 19, 1974·Nature·M G Sargent
Jan 1, 1970·Molecular & General Genetics : MGG·D Karamata, J D Gross
Apr 1, 1971·Journal of Bacteriology·E Ephrati-Elizur, S Borenstein
Apr 1, 1980·Journal of Bacteriology·M HolmesO Pierucci
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·M E Sharpe, J Errington
Jul 1, 1995·Journal of Bacteriology·P M Hauser, J Errington
Jan 1, 1995·Annual Review of Cell and Developmental Biology·C Wu
Jan 1, 1995·Annual Review of Genetics·R G Wake, J Errington
Oct 1, 1996·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·P J LewisJ Errington
Jun 1, 1996·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·O ResnekovR Losick
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·D C LinA D Grossman
Apr 1, 1962·Journal of General Microbiology·J F COLLINS, M H RICHMOND

❮ Previous
Next ❯

Citations

May 3, 2008·Folia Microbiologica·N PavlendováI Barák
Aug 28, 2001·Journal of Biotechnology·C Bignell, C M Thomas
Jan 28, 2003·Trends in Genetics : TIG·Jonathan Dworkin
Mar 31, 1999·Trends in Genetics : TIG·M E Sharpe, J Errington
Feb 18, 1998·Biochimie·S AutretS J Séror
Dec 22, 1999·Current Opinion in Cell Biology·R B Jensen, L Shapiro
Oct 26, 2000·Trends in Cell Biology·R B Jensen, L Shapiro
May 18, 2001·Trends in Cell Biology·A S Belmont
Jul 6, 2000·Trends in Microbiology·J Møller-JensenK Gerdes
Jul 24, 1998·Trends in Microbiology·W Margolin
Feb 13, 2001·Molecular Cell·K P Lemon, A D Grossman
Dec 4, 2001·Current Opinion in Microbiology·J Errington
Mar 6, 1999·Current Opinion in Microbiology·J A Hoch
Mar 6, 1999·Current Opinion in Microbiology·J Lutkenhaus
Mar 6, 1999·Current Opinion in Microbiology·D C Fung, J A Theriot
Mar 6, 1999·Current Opinion in Microbiology·P A Levin, A D Grossman
Jan 18, 2006·Nature Reviews. Microbiology·Finbarr Hayes, Daniela Barillà
Mar 24, 2004·Nature Reviews. Microbiology·Jeff Errington
Nov 9, 2000·Molecular Microbiology·T WeitaoK Nordström
Sep 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Idit Anna BerlatzkySigal Ben-Yehuda
Aug 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Daniel Muñoz-EspínMargarita Salas
Feb 17, 2000·The EMBO Journal·P J LewisJ Errington
Feb 14, 2002·Nucleic Acids Research·M LukaszewiczG Jagura-Burdzy
Mar 21, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A DanchinP Nitschké
Jun 30, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·I Hautefort, J C Hinton
May 18, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jeff ErringtonLing Juan Wu
May 18, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thomas A LeonardJan Löwe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.