Dynamic model of vascular-targeted photodynamic therapy

Computer Methods in Biomechanics and Biomedical Engineering
Xiao-Ming HuYi Zhao

Abstract

Vascular-targeted photodynamic therapy has shown efficiency in treating port wine stains. A dynamic model that incorporates blood flow, kinetic diffusion, oxygen and photosensitizer consumption and reaction, and light modulation is proposed to reveal the interactions among light, photosensitizer, and oxygen. Simulation results show that pulse light modulation synchronized with heartbeats hold the advantage of increased singlet oxygen accumulation, higher oxygen concentration and lower temperature. Meanwhile, constant light treatment is advantageous in terms of higher temperature, lower total oxygen concentration and singlet oxygen accumulation. Therefore, the optimized treatment protocol may involve a balance among the phototoxicity, hypoxia, and photothermolysis.

References

Apr 27, 1998·Optics Express·J BartonM Van Gemert
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Feb 7, 2012·Journal of the American Academy of Dermatology·Jennifer K ChenMichal Heger
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Dec 4, 2012·Photodiagnosis and Photodynamic Therapy·Kai-Hua YuanZheng Huang
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Sep 1, 2007·Photodiagnosis and Photodynamic Therapy·Nai-Yan Huang
Mar 6, 2015·Journal of Biomedical Optics·Timothy C ZhuRozhin Penjweini

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Citations

Apr 22, 2020·Photodiagnosis and Photodynamic Therapy·Sun WangSheng-Xiu Liu

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Methods Mentioned

BETA
light treatment

Software Mentioned

COMSOL Multiphysics

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