Dynamic Modulation of Myelination in Response to Visual Stimuli Alters Optic Nerve Conduction Velocity

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Ainhoa EtxeberriaJonah R Chan

Abstract

Myelin controls the time required for an action potential to travel from the neuronal soma to the axon terminal, defining the temporal manner in which information is processed within the CNS. The presence of myelin, the internodal length, and the thickness of the myelin sheath are powerful structural factors that control the velocity and fidelity of action potential transmission. Emerging evidence indicates that myelination is sensitive to environmental experience and neuronal activity. Activity-dependent modulation of myelination can dynamically alter action potential conduction properties but direct functional in vivo evidence and characterization of the underlying myelin changes is lacking. We demonstrate that in mice long-term monocular deprivation increases oligodendrogenesis in the retinogeniculate pathway but shortens myelin internode lengths without affecting other structural properties of myelinated fibers. We also demonstrate that genetically attenuating synaptic glutamate neurotransmission from retinal ganglion cells phenocopies the changes observed after monocular deprivation, suggesting that glutamate may constitute a signal for myelin length regulation. Importantly, we demonstrate that visual deprivation and short...Continue Reading

Citations

Apr 12, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Anna Klingseisen, David A Lyons
Mar 21, 2018·Nature Neuroscience·Robert A HillJaime Grutzendler
Apr 6, 2018·Annual Review of Neuroscience·Ragnhildur T Káradóttir, Chay T Kuo
Sep 13, 2018·Journal of Neurophysiology·Alberto LazariCassandra Sampaio-Baptista
Sep 19, 2018·Journal of Neurochemistry·Omar de FariaJunhua Xiao
Jan 22, 2019·Nature Communications·Xiaojun ZhangJianhai Xiang
Apr 9, 2019·Glia·Chloé HabermacherNajate Benamer
Jun 25, 2019·Glia·Daumante SuminaiteMatthew R Livesey
Apr 30, 2019·Glia·Robert A Hill, Jaime Grutzendler
Sep 25, 2017·Developmental Neurobiology·Omar de FariaRagnhildur Thóra Káradóttir
Mar 2, 2018·Evolution, Medicine, and Public Health·Riley M Bove
Sep 13, 2019·Nature Communications·Alexandria N Hughes, Bruce Appel
Aug 24, 2017·Developmental Neurobiology·Marie E BechlerCharles Ffrench-Constant
Sep 20, 2017·Developmental Neurobiology·Bethany R Kondiles, Philip J Horner
Jun 20, 2018·Proceedings of the National Academy of Sciences of the United States of America·Denise M PiscopoCristopher M Niell
Dec 7, 2018·Frontiers in Cellular Neuroscience·Zahraa ChorghayEdward S Ruthazer
Aug 28, 2019·The Journal of Cell Biology·Nimrod ElazarElior Peles
Feb 12, 2020·Nature Neuroscience·Simon PanMazen A Kheirbek
Mar 18, 2020·Frontiers in Cellular Neuroscience·Remi RonzanoAnne Desmazieres
Apr 27, 2017·Neurochemical Research·Robert Fern
Dec 30, 2017·Expert Review of Neurotherapeutics·Christopher E McMurranRobin Jm Franklin
Apr 26, 2018·Neural Plasticity·Mara Nickel, Chen Gu
Jul 3, 2020·Frontiers in Cell and Developmental Biology·Helena S DominguesFábio G Teixeira
Jul 1, 2020·Frontiers in Cellular Neuroscience·Giulia BonettoRagnhildur Thóra Káradóttir
Jul 19, 2017·Annual Review of Vision Science·Kalanit Grill-SpectorJesse Gomez
Oct 26, 2018·Frontiers in Cellular Neuroscience·Laura Fontenas, Sarah Kucenas
Oct 18, 2019·Frontiers in Cellular Neuroscience·Pepe Alcami, Ahmed El Hady
Oct 29, 2019·ELife·Matthew SwireCharles Ffrench-Constant
May 22, 2019·International Journal of Molecular Sciences·Maria Ceprian, Daniel Fulton
Jun 18, 2020·Cerebral Cortex·Colin T Lockwood, Charles J Duffy
Sep 20, 2017·Developmental Neurobiology·Patrick LongGabriel Corfas
Oct 23, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nicolas J GuehlPedro Brugarolas
Jul 1, 2020·Neurobiology of Disease·Daniel K Wilton, Beth Stevens

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