Dynamic-module redundancy confers robustness to the gene regulatory network involved in hair patterning of Arabidopsis epidermis

Bio Systems
Mariana Benítez, Elena R Alvarez-Buylla

Abstract

Redundancy among dynamic modules is emerging as a potentially generic trait in gene regulatory networks. Moreover, module redundancy could play an important role in network robustness to perturbations. We explored the effect of dynamic-module redundancy in the networks associated to hair patterning in Arabidopsis root and leaf epidermis. Recent studies have put forward several dynamic modules belonging to these networks. We defined these modules in a discrete dynamical framework that was previously reported. Then, we addressed whether these modules are sufficient or necessary for recovering epidermal cell types and patterning. After defining two quantitative estimates of the system's robustness, we also compared the robustness of each separate module with that of a network coupling all the leaf or root modules. We found that, considering certain assumptions, all the dynamic modules proposed so far are sufficient on their own for pattern formation, but reinforce each other during epidermal development. Furthermore, we found that networks of coupled modules are more robust to perturbations than single modules. These results suggest that dynamic-module redundancy might be an important trait in gene regulatory networks and point at...Continue Reading

References

May 19, 2000·Journal of Theoretical Biology·L Mendoza, E R Alvarez-Buylla
Jul 26, 2000·Nature·G von DassowG M Odell
Jan 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Henrik JönssonEric Mjolsness
Jan 20, 2007·Biochemical Society Transactions·S SchellmannJ Uhrig
Sep 22, 2007·Plant Physiology·Kengo MorohashiErich Grotewold
Feb 9, 2008·Annual Review of Plant Biology·Tetsuya IshidaTakuji Wada
Jul 4, 2008·Bioinformatics·Yung-Keun Kwon, Kwang-Hyun Cho
Sep 4, 2008·Molecular Systems Biology·Simona DigiuniMartin Hulskamp
Jan 29, 2009·Journal of Experimental Botany·John SchiefelbeinAngela Bruex
Apr 21, 2009·The International Journal of Developmental Biology·Stuart A Newman, Ramray Bhat

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Citations

Jul 7, 2011·Nature Reviews. Molecular Cell Biology·Elena R Alvarez-BuyllaCarlos Espinosa-Soto
Jul 19, 2011·Artificial Life·Rodrigo Poblanno-Balp, Carlos Gershenson
Oct 6, 2010·BMC Systems Biology·Eugenio AzpeitiaElena R Alvarez-Buylla
Nov 15, 2011·Current Opinion in Plant Biology·Markus Grebe
Jan 25, 2011·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Mariana BenítezElena R Alvarez-Buylla
May 1, 2012·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Lorena CaballeroGerminal Cocho
Dec 12, 2012·Current Opinion in Plant Biology·Mariana BenítezElena R Alvarez-Buylla
Jan 5, 2013·Current Opinion in Plant Biology·Kook Hui RyuJohn Schiefelbein
Jun 25, 2014·Frontiers in Plant Science·Valeria Hernández-HernándezMariana Benítez
Jan 24, 2015·PloS One·Nasimul NomanHitoshi Iba
Jun 2, 2016·Development·Jorge E Salazar-HenaoWolfgang Schmidt
Mar 19, 2019·The New Phytologist·Elena R Alvarez-BuyllaAdriana Garay-Arroyo
Nov 15, 2016·Frontiers in Plant Science·Pawel KrupinskiHenrik Jönsson
Jun 1, 2021·Interface Focus·Johannes Jaeger, Nick Monk

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