Dynamic Neuron-Glia Interactions in an Oscillatory Network Controlling Behavioral Plasticity in the Weakly Electric Fish, Apteronotus leptorhynchus

Frontiers in Physiology
Gunther K H Zupanc

Abstract

The involvement of glial cells in the regulation of physiological functions is being increasingly recognized, yet their role in plasticity of neural oscillators has remained largely elusive. An excellent model system to address the latter function is the pacemaker nucleus of the weakly electric fish, Apteronotus leptorhynchus. This brainstem oscillator drives the fish's electric organ discharge in a one-to-one fashion, with median frequencies of 880 Hz in males and 740 Hz in females. Morphometric analysis of the pacemaker nucleus has shown that astrocytes outnumber mature neurons seven-fold, and oscillator neurons even 200-fold. A similar dominance of astrocytes occurs among the adult-born cells that differentiate into glia and neurons. The astrocytes form a dense meshwork of cells interconnected by gap junctions. The degree of association of astrocytic fibers with the neural oscillator cells, and the gap-junction coupling between individual astrocytes, exhibit a sexual dimorphism, which parallels the sexual dimorphisms in the output frequency of the pacemaker nucleus, and ultimately in the electric organ discharge of the fish. It is hypothesized that the dynamics in astroglial structure mediate differences in the capacity to b...Continue Reading

References

Jan 1, 1988·Journal of Neurophysiology·S F Traynelis, R Dingledine
Oct 1, 1986·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·A H BassD B Kelley
Mar 1, 1987·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·J H MeyerC H Keller
Aug 1, 1987·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·J Dye, W Heiligenberg
Oct 1, 1994·Progress in Neurobiology·L M García-SeguraF Naftolin
Jun 30, 1994·Nature·V ParpuraP G Haydon
Jan 1, 1997·Annual Review of Neuroscience·G I Hatton
Nov 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·E D LaywellD A Steindler
Jul 16, 2003·The European Journal of Neuroscience·Sarah L LangleDionysia T Theodosis
Apr 16, 2004·Journal of Neurobiology·Elzbieta Pyza, Jolanta Górska-Andrzejak
Nov 25, 2004·Neuroscience·P Kofuji, E A Newman
Apr 25, 2006·Brain : a Journal of Neurology·J D JirschJ Gotman
Jul 16, 2008·Physiological Reviews·Dionysia T TheodosisStéphane H R Oliet
Feb 10, 2009·Brain Structure & Function·Claus C Hilgetag, Helen Barbas
Oct 8, 2011·Journal of Physiology, Paris·Christian Giaume, Xinhe Liu
Apr 5, 2012·Science Signaling·Fushun WangMaiken Nedergaard
Jun 14, 2013·Journal of Neurophysiology·Allison PearceWilliam C Stacey
Nov 19, 2013·Nature Medicine·Vinita Rangroo ThraneMaiken Nedergaard
Jan 31, 2014·Journal of Neurophysiology·Günther K H ZupancMarianne M Zupanc
Mar 19, 2014·Developmental Neurobiology·Ruxandra F SîrbulescuGünther K H Zupanc
Dec 17, 2014·Cold Spring Harbor Perspectives in Biology·Philip G Haydon, Maiken Nedergaard
Nov 21, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lisa RouxChristian Giaume
May 18, 2016·The Journal of Comparative Neurology·Christopher S von BartheldSuzana Herculano-Houzel
Mar 28, 2017·Current Biology : CB·Chak Foon TsoErik D Herzog

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Citations

Dec 15, 2018·Developmental Neurobiology·Vladimir Mashanov, Olga Zueva
Oct 9, 2020·Scientific Reports·Aaron R ShifmanJohn E Lewis
Aug 28, 2020·Reviews in the Neurosciences·Dorothea DereEkrem Dere

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Methods Mentioned

BETA
electron microscopy

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