Dynamic nucleosomes and gene transcription

Trends in Genetics : TIG
Jane Mellor

Abstract

Gene transcription occurs on a nucleosomal template known as chromatin. The recruitment of the transcriptional regulators and the transcription machinery to promoter chromatin is coordinated by a genetic code on the DNA and an epigenetic code on the histone proteins. Chromatin is not a stable environment; rather, the histones, the transcription regulatory proteins and the enzymes that modify and mobilise nucleosomes are in a dynamic state. Thus, at any one time, the factors associated with a region will cooperate or compete to change the rate of inter-conversion between permissive and non-permissive chromatin states, leading to activation or repression of transcription. Here, new concepts such as dynamic nucleosomes and a dynamic histone code in gene transcription are explored.

Citations

Jan 21, 2014·Molecular and Cellular Endocrinology·Damien A LeachGrant Buchanan
Dec 18, 2013·Nature Reviews. Genetics·Ty C Voss, Gordon L Hager
Jul 25, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ricco LindnerSimone Di Giovanni
May 9, 2012·Annual Review of Cell and Developmental Biology·Peter L Freddolino, Saeed Tavazoie
Dec 21, 2006·Nucleic Acids Research·Kohsuke KatoKyosuke Nagata
Mar 28, 2007·Molecular and Cellular Biology·Helder FerreiraTom Owen-Hughes
Jul 13, 2007·Nucleic Acids Research·Fei XiaoWilliam T Garrard
Oct 26, 2007·The Journal of Biological Chemistry·Gawain McCollGordon J Lithgow
Nov 23, 2007·Genome Research·Martin C FrithAlbin Sandelin
Aug 20, 2008·Molecular and Cellular Biology·Ales ObrdlikPiergiorgio Percipalle
Sep 26, 2008·The Journal of Biological Chemistry·Andrea UjváriDonal S Luse
Mar 18, 2009·World Journal of Gastroenterology : WJG·Blythe D Shepard, Pamela L Tuma
Jun 24, 2009·Genome Research·Alexander E SmithN Shaun B Thomas
Jun 27, 2009·Journal of the American Society of Nephrology : JASN·Masayo NaitoKarol Bomsztyk
Jul 3, 2009·Genes & Development·Jurgi CamblongFrançoise Stutz
Oct 2, 2009·Molecular Biology of the Cell·Sabrina FritahClaire Vourc'h
Nov 17, 2009·PLoS Computational Biology·Eivind ValenAnders Krogh
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Michael C LawrenceMelanie H Cobb
Dec 25, 2009·American Journal of Physiology. Renal Physiology·Richard A Zager, Ali C M Johnson
Nov 16, 2010·Epigenetics & Chromatin·Christoforos NikolaouRoderic Guigó
Jun 8, 2011·Molecular and Cellular Biology·Shan-Shan WangJin-Qiu Zhou
Aug 19, 2011·The Journal of Biological Chemistry·Bo O Zhou, Jin-Qiu Zhou
Oct 11, 2011·The Journal of Biological Chemistry·Irit KapellerJoseph Shlomai
Apr 30, 2013·BMC Genomics·George LockeAlexandre V Morozov
Oct 4, 2011·Cellular and Molecular Life Sciences : CMLS·Peter Sarkies, Julian E Sale
Aug 23, 2011·Journal of Statistical Physics·Răzvan V Chereji, Alexandre V Morozov
Aug 1, 2008·Experimental Brain Research·Maria SpolidoroLamberto Maffei
May 19, 2011·Nature Communications·Maria SpolidoroLamberto Maffei
Oct 17, 2014·Nutrients·Shalome A Bassett, Matthew P G Barnett

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.