Dynamic pattern generation in cell membranes: Current insights into membrane organization

Biochimica Et Biophysica Acta. Biomembranes
Krishnan Raghunathan, Anne K Kenworthy

Abstract

It has been two decades since the lipid raft hypothesis was first presented. Even today, whether these nanoscale cholesterol-rich domains are present in cell membranes is not completely resolved. However, especially in the last few years, a rich body of literature has demonstrated both the presence and the importance of non-random distribution of biomolecules on the membrane, which is the focus of this review. These new developments have pushed the experimental limits of detection and have brought us closer to observing lipid domains in the plasma membrane of live cells. Characterization of biomolecules associated with lipid rafts has revealed a deep connection between biological regulation and function and membrane compositional heterogeneities. Finally, tantalizing new developments in the field have demonstrated that lipid domains might not just be associated with the plasma membrane of eukaryotes but could potentially be a ubiquitous membrane-organizing principle in several other biological systems. This article is part of a Special Issue entitled: Emergence of Complex Behavior in Biomembranes edited by Marjorie Longo.

Citations

Mar 15, 2019·Nanoscale·Selma DahmanePierre-Emmanuel Milhiet
Jan 3, 2020·Molecular Biology of the Cell·Nirmalya BagBarbara A Baird
Sep 15, 2020·Frontiers in Molecular Neuroscience·Michihiro IgarashiMotohiro Nozumi
Oct 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Agnieszka ChytłaAleksander Czogalla
Jun 22, 2021·Current Opinion in Colloid & Interface Science·Miriam SimonMichael Gradzielski
Aug 14, 2020·The Journal of Physical Chemistry. B·Abhilash Sahoo, Silvina Matysiak
Aug 27, 2021·Toxins·Anne K KenworthyWayne I Lencer

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