Dynamic patterns of expression of BMP isoforms 2, 4, 5, 6, and 7 during chicken heart development

The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology
Semir SomiMaurice J B Van Den Hoff

Abstract

Bone morphogentic proteins (BMPs) play an important role in cardiac development. Using an in vitro explant analysis, we show that BMPs are crucial for myocardium formation. As a first approach to identify which BMP may be involved in myocardium formation in intra- and extracardiac mesenchyme in vivo, a survey of the expression patterns of BMP2, -4, -5, -6, and -7 mRNA is prepared by in situ hybridization in chicken embryonic hearts from HH5 to 44. During recruitment of mesodermal cells to the outflow tract myocardium (HH10-23), BMP2, -4, -5, and -7 mRNA are expressed in the distal myocardial border and the flanking mesenchyme. After completion, BMP2 and -4 mRNA become restricted to the mesenchyme and BMP5 and -7 mRNA to the myocardium. At the venous pole, BMP2, -5, and -7 mRNA are expressed in the distal myocardial border of the caval vein, while BMP2, -5, -6, and -7 mRNA are expressed in the distal myocardium around the pulmonary vein. BMP4 mRNA is expressed in the adjacent mesenchyme at both sides. During muscularization of the atrioventricular cushions and the tricuspid valve, the cardiomyocytes that protrude into the mesenchyme express BMP2, -4, -5, and -7 mRNA, whereas BMP6 mRNA is expressed in the cushion mesenchyme. The ...Continue Reading

References

Jan 1, 1973·Journal of Ultrastructure Research·S Virágh, C E Challice
Jan 1, 1995·Circulation·W H LamersR H Anderson
Jun 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·W K JonesJ Robbins
Jul 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·P S Chan-ThomasP J Barton
Feb 15, 1997·Genes & Development·T M SchultheissA B Lassar
Apr 18, 1998·Circulation Research·A F MoormanW H Lamers
Oct 9, 1998·Anatomy and Embryology·P W OosthoekA C Gittenberger-de Groot
Aug 6, 1999·Developmental Biology·M J van den HoffA Wessels
Feb 11, 2000·Annals of the New York Academy of Sciences·R MerinoJ M Hurle
Mar 8, 2000·Mechanisms of Development·T SchlangeT Brand
Jul 6, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C MillinoS Ausoni
Dec 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A F MoormanV M Christoffels
Feb 13, 2001·Genes & Development·E Tzahor, A B Lassar
Feb 13, 2001·Genes & Development·M J MarvinA B Lassar
Jun 20, 2001·Developmental Biology·S P AllenM K Richardson
Oct 12, 2001·The Anatomical Record·S R QayyumM K Richardson
Jan 11, 2002·Developmental Biology·C H MjaatvedtR R Markwald
Jan 11, 2002·Developmental Biology·M J van den HoffA Wessels
Jan 15, 2002·The Anatomical Record·Arjan C HouwelingVincent M Christoffels
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Vinciane GaussinMichael D Schneider
Apr 5, 2002·Trends in Genetics : TIG·Robert G Kelly, Margaret E Buckingham
Jul 27, 2002·Circulation Research·Wouter H Lamers, Antoon F M Moorman
Nov 21, 2002·Development·Emmanuèle C DélotKaren M Lyons
Dec 14, 2002·Genesis : the Journal of Genetics and Development·Guang-Quan Zhao
Mar 12, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Boudewijn P T KruithofAntoon F M Moorman
May 22, 2003·Cardiovascular Research·Mark J Solloway, Richard P Harvey
Jan 1, 1951·Journal of Morphology·V HAMBURGER, H L HAMILTON

❮ Previous
Next ❯

Citations

Mar 17, 2009·Anatomical Science International·Toshiyuki YamagishiHiroaki Nakamura
Feb 19, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ivan P MoskowitzChristine E Seidman
Apr 29, 2011·Cardiovascular Research·Carmen López-Sánchez, Virginio García-Martínez
Jul 10, 2008·Physiological Genomics·Santanu ChakrabortyKatherine E Yutzey
Aug 13, 2010·Development·Mary Redmond HutsonMargaret L Kirby
May 12, 2011·Development·Danyal HamiMargaret L Kirby
Sep 18, 2012·PloS One·Bjarke JensenVincent M Christoffels
Mar 29, 2014·Acta Biomaterialia·S JanaR D Simari
Nov 20, 2012·Cellular and Molecular Life Sciences : CMLS·Victoria C GarsidePamela A Hoodless
Jun 5, 2012·Differentiation; Research in Biological Diversity·Boudewijn P T KruithofMarie-José Goumans
Mar 5, 2015·Cell Cycle·Guang WangXuesong Yang
Apr 7, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mattabhorn PhimphilaiRenny T Franceschi
Apr 18, 2008·Birth Defects Research. Part A, Clinical and Molecular Teratology·Jizhen ChenKersti K Linask
Dec 28, 2010·Developmental Biology·Takatoshi TsuchihashiDeepak Srivastava
Dec 8, 2009·Developmental Biology·Christina M AlfieriKatherine E Yutzey
Oct 20, 2009·Developmental Biology·Laura A Dyer, Margaret L Kirby
Oct 27, 2006·Developmental Biology·Elaine L Shelton, Katherine E Yutzey
May 9, 2006·Developmental Biology·Jan SchlueterThomas Brand
Jun 7, 2006·Developmental Biology·Boudewijn P T KruithofMaurice J B van den Hoff
Oct 6, 2010·Developmental Biology·Laura A DyerMargaret L Kirby
Jun 10, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Shaad M Ahmad
Mar 10, 2018·Current Cardiology Reports·Punashi Dutta, Joy Lincoln
Jan 9, 2015·Molecular Biology of the Cell·Guang WangXuesong Yang
Mar 3, 2018·Circulation Research·Hui ZhangBin Zhou
Feb 19, 2005·Circulation Research·Maurice J B van den Hoff, Antoon F M Moorman
Jun 6, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Gert van den BergMaurice J B van den Hoff
May 8, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Masahide SakabeYuji Nakajima
Apr 21, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roong Zhao, Stephen A Duncan
Feb 28, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Iris MoralezAndy Wessels
Apr 3, 2019·Development·Tanya E FoleyDavid Lohnes
May 2, 2013·American Journal of Medical Genetics. Part a·Marc SylvaAntoon F M Moorman
Oct 20, 2019·Development·Verónica A LombardoSalim Abdelilah-Seyfried
May 17, 2017·Molecular Neurobiology·Guang WangXuesong Yang
Feb 28, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bin ZhaoD Woodrow Benson
Nov 22, 2018·Frontiers in Cardiovascular Medicine·Vinal Menon, Joy Lincoln
Jan 31, 2017·Journal of Cardiovascular Development and Disease·Tara BurnsAndy Wessels
Sep 15, 2007·Development·Yasuo IshiiTakashi Mikawa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.