Dynamic processing of taste aversion extinction in the brain

Brain Research
G Andrew MickleyDawn R Remmers-Roeber

Abstract

While substantial advances have been made in discovering how the brain learns and remembers, less is known about how the brain discards information, reorganizes information, or both. These topics are not only relevant to normal brain functioning but also speak to pathologies in which painful memories do not wane but are evoked time and again (e.g., post-traumatic stress disorder; PTSD). Here, we measured brain activity (as indicated by the regional expression of c-Fos protein) in rats during acquisition and throughout extinction of a conditioned taste aversion (CTA). We compared that brain activity with animals that had intact CTA memories or those that experienced an explicitly unpaired (EU) conditioned stimulus (CS; saccharin, SAC) and unconditioned stimulus (US; lithium chloride, LiCl). The data show a dynamic and nonuniform pattern of c-Fos protein expression in brain nuclei known to mediate gustation and CTAs. In particular, brainstem nuclei (e.g., nucleus of the solitary tract; NTS) and the basolateral nucleus of the amygdala (BLA) are active early as CTAs are formed and as extinction of the learned response begins. Later in the extinction process, the BLA reduces c-Fos expression relative to nonextinguished controls. Fin...Continue Reading

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Citations

Oct 21, 2006·Nature Reviews. Neuroscience·Sidney A SimonMiguel A L Nicolelis
Feb 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Riccardo Accolla, Alan Carleton
Jun 9, 2012·BMC Neuroscience·Dave J Hayes, Georg Northoff
Dec 3, 2014·Physiology & Behavior·Hisanori TsuboiMakoto Funahashi
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Jul 3, 2007·Journal of Neuroimmunology·Maj-Britt NiemiGustavo Pacheco-López
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Feb 8, 2011·Medical & Biological Engineering & Computing·Katarzyna J Blinowska
Sep 29, 2019·Journal of Alzheimer's Disease : JAD·Ilona Har-PazAnan Moran

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