Sep 2, 2015

Dynamic reconfiguration of frontal brain networks during executive cognition in humans

Proceedings of the National Academy of Sciences of the United States of America
Urs BraunDanielle S Bassett

Abstract

The brain is an inherently dynamic system, and executive cognition requires dynamically reconfiguring, highly evolving networks of brain regions that interact in complex and transient communication patterns. However, a precise characterization of these reconfiguration processes during cognitive function in humans remains elusive. Here, we use a series of techniques developed in the field of "dynamic network neuroscience" to investigate the dynamics of functional brain networks in 344 healthy subjects during a working-memory challenge (the "n-back" task). In contrast to a control condition, in which dynamic changes in cortical networks were spread evenly across systems, the effortful working-memory condition was characterized by a reconfiguration of frontoparietal and frontotemporal networks. This reconfiguration, which characterizes "network flexibility," employs transient and heterogeneous connectivity between frontal systems, which we refer to as "integration." Frontal integration predicted neuropsychological measures requiring working memory and executive cognition, suggesting that dynamic network reconfiguration between frontal systems supports those functions. Our results characterize dynamic reconfiguration of large-scale...Continue Reading

  • References52
  • Citations73

References

  • References52
  • Citations73

Mentioned in this Paper

Memory, Short-Term
Immediate Recall
Patterns
Schizophrenia
Brain
Executive Function
Neural Stem Cells
Structure of Cortex of Kidney
Teens
Structure of Broca's Area

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.