Dynamic regulation of gastric autoimmunity by thyroid hormone

International Immunology
J WangJ R Klein

Abstract

Neonatal thymectomy (NTX) of BALB/c mice between days 1 and 3 post-birth leads to a high incidence of autoimmune gastritis involving T cells and autoantibodies. Although progress has been made in understanding various immunological events associated with that disease process, much remains to be learned about the regulatory factors which control autoimmune gastritis. In this study we have examined the potential for neuroendocrine hormones of the hypothalamus-pituitary-thyroid (HPT) axis to alter the outcome of experimental autoimmune gastritis in NTX mice. As reported here, thyroxine administered to young adult NTX mice during an active phase of disease development dramatically reduced the incidence of gastritis and the overall severity of disease, and lowered the levels of anti-parietal cell antibodies. In contrast, treatment of young NTX mice with thyroxine or other HPT hormones prior to the onset of disease had no beneficial effect on gastritis, but instead resulted in significantly higher anti-parietal cell antibody levels compared to non-hormone-treated NTX mice or to NTX mice treated as adults. Reverse transcriptase spectratype analyses of 22 Vbeta gene junctional sites revealed pronounced oligoclonality and limited juncti...Continue Reading

Citations

Dec 1, 1999·Developmental and Comparative Immunology·J R Klein
Aug 9, 2013·International Journal of Molecular Sciences·Adam R BrownFrank A Simmen
Aug 11, 1998·Biochemical Pharmacology·J R Klein
Jan 6, 2004·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ahmed Al Moutaery
Mar 26, 2005·The Journal of International Medical Research·E G KandemirY Narin
Feb 19, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Michael TorbensonTsung-Teh Wu
Jan 18, 2020·Journal of Clinical Medicine·Maria Pina DoreGiovanni Mario Pes

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