Dynamic regulation of PIF5 by COP1-SPA complex to optimize photomorphogenesis in Arabidopsis

The Plant Journal : for Cell and Molecular Biology
Vinh Ngoc PhamEnamul Huq

Abstract

Light signal provides the spatial and temporal information for plants to adapt to the prevailing environmental conditions. Alterations in light quality and quantity can trigger robust changes in global gene expression. In Arabidopsis thaliana, two groups of key factors regulating those changes in gene expression are CONSTITUTIVE PHOTOMORPHOGENESIS/DEETIOLATED/FUSCA (COP/DET/FUS) and a subset of basic helix-loop-helix transcription factors called PHYTOCHROME-INTERACTING FACTORS (PIFs). Recently, rapid progress has been made in characterizing the E3 ubiquitin ligases for the light-induced degradation of PIF1, PIF3 and PIF4; however, the E3 ligase(s) for PIF5 remains unknown. Here, we show that the CUL4COP1-SPA complex is necessary for the red light-induced degradation of PIF5. Furthermore, COP1 and SPA proteins stabilize PIF5 in the dark, but promote the ubiquitination and degradation of PIF5 in response to red light through the 26S proteasome pathway. Genetic analysis illustrates that overexpression of PIF5 can partially suppress both cop1-4 and spaQ seedling de-etiolation phenotypes under dark and red-light conditions. In addition, the PIF5 protein level cycles under both diurnal and constant light conditions, which is also def...Continue Reading

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Citations

Sep 29, 2019·Nature Communications·Ashutosh SharmaKeara A Franklin
Feb 16, 2020·Physiologia Plantarum·David S Favero
Sep 19, 2019·Nature Communications·Inyup PaikEnamul Huq
Jul 31, 2020·Journal of Integrative Plant Biology·Liwen YangRongcheng Lin
Nov 21, 2019·Nature Communications·Martina LegrisChristian Fankhauser
Oct 10, 2018·The Plant Journal : for Cell and Molecular Biology·Sheila McCormick
Sep 29, 2020·The Plant Journal : for Cell and Molecular Biology·David S FaveroKeiko Sugimoto
May 1, 2021·Molecular Plant·Jianqin HaoYunhai Li
Mar 24, 2021·Annual Review of Plant Biology·Mei-Chun ChengEnamul Huq

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