Dynamic release of gentamicin sulfate (GS) from alginate dialdehyde (AD)-crosslinked casein (CAS) films for antimicrobial applications

Designed Monomers and Polymers
S K BajpaiM Bajpai

Abstract

In the present work, antibiotic drug gentamicin sulfate (GS) has been loaded into alginate dialdehyde-crosslinked casein (CAS) films for wound dressing applications. The films have been characterized by Fourier transform infrared spectroscopy, X-ray diffraction analysis and scanning electron microscopy. The dynamic release of model drug GS has been investigated in the physiological fluid at 37 °C. The drug release data has been interpreted in the terms of various kinetic models such as Power function model, first order model and Schott model. The release data was found to be well fitted by Schott model. The various diffusion coefficients are also evaluated. The adsorption of model therapeutic protein BSA on the film has been investigated. The maximum adsorption is found to be 5.7 mg/cm2.The films were tested for their antibacterial and anti-fungal action. Finally, thein vivowound healing study was carried out on Albino wistar rats.

References

Feb 21, 2006·International Journal of Pharmaceutics·Sakchai Wittaya-areekul, Chureerat Prahsarn
Apr 14, 2006·Journal of Occupational Health·Tomoko Takigawa, Yoko Endo
May 14, 2009·Biomacromolecules·Arun GhoshGeorge J Dias
Mar 6, 2010·Molecular Nutrition & Food Research·Dragana StanicTanja Cirkovic Velickovic
May 4, 2010·Colloids and Surfaces. B, Biointerfaces·Fei SongNan-Nan Li
Dec 6, 2014·Journal of Food Science and Technology·Y R WaghB Surendra Nath
Dec 9, 2014·International Journal of Biological Macromolecules·Yu ZhuangRonald Gebhardt
Jan 14, 2016·PloS One·Carl T GustafsonMichael J Yaszemski
Jan 19, 2016·International Journal of Biological Macromolecules·Thawatchai PhaechamudWiwat Pichayakorn
Mar 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bapi SarkerAldo R Boccaccini

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Citations

Mar 9, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaoli KongJun Wu
Mar 13, 2021·Advanced Sustainable Systems·Sanjana GopalakrishnanVincent M Rotello

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Methods Mentioned

BETA
scanning electron microscopy
X-ray
equilibrium adsorption

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