Dynamic Remodeling of the Host Cell Membrane by Virulent Mycobacterial Sulfoglycolipid-1

Scientific Reports
Manjari MishraShobhna Kapoor

Abstract

Lipids dictate membrane properties to modulate lateral membrane organization, lipid/protein diffusion and lipid-protein interactions, thereby underpinning proper functioning of cells. Mycobacterium tuberculosis harnesses the power of its atypical cell wall lipids to impact immune surveillance machinery centered at the host cell membrane. However, the role of specific virulent lipids in altering host cellular functions by modulating membrane organization and the associated signaling response are still pertinent unresolved questions. Here, combining membrane biophysics and cell biology, we elucidate how virulent Mtb sulfoglycolipids hijack the host cell membrane, affecting its order, fluidity, and stiffness along with manipulating the linked cytoskeleton. The functional outcome of this perturbation was assayed by monitoring membrane-associated autophagy signaling. These actions form a part of the overall response to commandeer host membrane-associated immune processes during infection. The findings on the mechanism of action of Mtb lipids on host cell membrane structure and downstream signaling will deepen the collective understanding of their functional aspects in membrane-dictated bacterial survival, pathogenesis and drug resis...Continue Reading

References

Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·M B GorenJ A Armstrong
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B J SpargoJ H Crowe
Apr 18, 2000·Infection and Immunity·I Guérin, C de Chastellier
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Rutilio A FrattiVojo Deretic
Dec 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Katharina GausWendy Jessup
Mar 6, 2004·The Journal of Biological Chemistry·Pilar DomenechClifton E Barry
Sep 27, 2005·Biophysical Journal·Mingzhai SunMichel Grandbois
Jul 30, 2009·Progress in Lipid Research·Ynske P M van der Meer-JanssenJ Bernd Helms
Dec 17, 2009·The Journal of Experimental Medicine·Eri IshikawaSho Yamasaki
Jul 19, 2011·Nature Reviews. Microbiology·Hyeilin HamKim Orth
Mar 1, 2012·ACS Chemical Biology·Sarah A GilmoreCarolyn R Bertozzi
Jun 15, 2012·Advances in Experimental Medicine and Biology·Amitabha Chattopadhyay, Md Jafurulla
Oct 19, 2012·Virulence·Marina A ForrelladFabiana Bigi
Mar 1, 1995·Journal of Fluorescence·T Parasassi, E Gratton
Jan 21, 2014·Cell Host & Microbe·M Sloan Siegrist, Carolyn R Bertozzi
Mar 19, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ritu Bansal-Mutalik, Hiroshi Nikaido
May 2, 2014·Biochimica Et Biophysica Acta·Saptarshi RoyAmitabha Chattopadhyay
Nov 25, 2014·Biophysical Journal·Godofredo BautistaMartti Kauranen
Mar 11, 2015·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Erdinc SezginChristian Eggeling
Feb 20, 2016·Current Opinion in Cell Biology·Marielle S KöberlinGiulio Superti-Furga
Feb 24, 2016·Chemistry and Physics of Lipids·G Aditya KumarAmitabha Chattopadhyay
Mar 8, 2016·Nature Reviews. Microbiology·Andrew J Olive, Christopher M Sassetti
Sep 14, 2016·The Journal of Membrane Biology·Carlos de la HabaJosé R Palacio
Nov 29, 2016·Drug Discovery Today·Chiara BorsariMaria Paola Costi
Mar 31, 2017·Nature Reviews. Molecular Cell Biology·Erdinc SezginChristian Eggeling
Aug 7, 2017·Science Advances·Sung-Tae YangLukas K Tamm
Oct 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Landry BlancJérôme Nigou

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Citations

Jun 6, 2020·International Journal of Molecular Sciences·Angel Ly, Jun Liu
Sep 15, 2020·Frontiers in Cellular and Infection Microbiology·Jacques AugenstreichCatherine Astarie-Dequeker
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Jacques Augenstreich, Volker Briken
Dec 15, 2020·Journal of Medicinal Chemistry·Gautam KumarShobhna Kapoor
Jul 15, 2021·Nature Cell Biology·Aurore Claude-TaupinVojo Deretic
Nov 12, 2020·European Journal of Microbiology & Immunology·Sadhana RoySomdeb BoseDasgupta
Nov 2, 2021·Medicinal Research Reviews·Prema K AgarwalaShobhna Kapoor

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Methods Mentioned

BETA
Polarization microscopy
AFM
PMA
transfection

Software Mentioned

Igor
Matlab
ImageJ
Origin
GraphPad Prism

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