PMID: 7009425Jan 1, 1981Paper

Dynamic responses of active and inactive renin in patients with essential and renovascular hypertension

Hypertension
W AoiK Hashiba

Abstract

We studied the dynamic responses of inactive renin and the form of renin released by the kidney in the hypertensive patients. Significant increase of active renin concentration (p less than 0.01) and decrease of the percentage of inactive renin concentration (p less than 0.01) after sodium depletion was observed in 15 essential hypertensive subjects with normal plasma renin activity. In eight of 15 patients, significant increase of inactive renin concentration (p less than 0.01) was observed after sodium depletion. In the remaining seven patients, no significant change of inactive renin concentration was demonstrated. A small increase of active and inactive renin concentration was observed following sodium depletion in six essential hypertensive subjects with low plasma renin activity (PRA). In the unilateral renal hypertension after upright tilting, active renin concentration in the renal vein of the affected kidney was significantly (p less than 0.02) higher than that in the renal vein of the non-affected kidney and the inferior vena cava. Inactive renin concentration in the renal vein of the affected kidney was significantly (p less than 0.02) lower than that in the renal vein of the nonaffected kidney and the inferior vena ...Continue Reading

References

Aug 1, 1977·Clinical Science and Molecular Medicine·R VandongenW H Birkenhäger
Jan 1, 1977·Advances in Experimental Medicine and Biology·B J LeckieJ Jordan
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Dec 7, 1972·Biochimica Et Biophysica Acta·B J Morris, E R Lumbers
Jan 1, 1974·Metabolism: Clinical and Experimental·D RabinowitzS Freier

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Citations

Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·K OgawaA Hara
Jan 1, 1986·The American Journal of Physiology·V J DzauP Dunckel

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