Dynamic status of metabolically healthy overweight/obesity and metabolically unhealthy and normal weight and the risk of type 2 diabetes mellitus: A cohort study of a rural adult Chinese population

Obesity Research & Clinical Practice
Bingyuan WangDongsheng Hu

Abstract

We aimed to determine dynamic status of metabolically healthy overweight or obesity (MHO) and metabolically unhealthy and normal weight (MUNW) and the risk of incident type 2 diabetes mellitus (T2DM). Body mass index and metabolic health were assessed on 11,865 eligible participants ≥18 years from 6-year follow-up cohort study of a rural Chinese population. Participants were classified as metabolically healthy and normal weight (MHNW), MHO, MUNW and metabolically unhealthy overweight or obesity (MUO) at both baseline and follow-up examinations. Hazard ratio (HR) and 95% confidence interval (CI) were used to assess baseline and their changes of BMI-metabolic status and the risk of incident T2DM. Risk of T2DM was increased for all participants with baseline MHO, MUNW, and MUO (adjusted HR 1.94, 95% CI 1.33-2.81; 3.10, 95% CI 2.19-4.39; and 6.63, 95% CI 4.94-8.90, all P<0.001, respectively). However, risk of T2DM was increased for participants with transformation from MHO to MUO (4.52, 95% CI 2.42-8.47, P<0.001) as compared with stable MHNW, but not stable MHO (0.53, 95CI 0.20-1.40, P=0.20). Risk of T2DM did not differ between participants with transformation from MUNW to metabolically healthy and those with stable MHNW (P>0.05), ...Continue Reading

Citations

Mar 24, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Klodian DhanaQi Sun
Apr 9, 2020·Menopause : the Journal of the North American Menopause Society·Sybil L Crawford
Feb 29, 2020·Menopause : the Journal of the North American Menopause Society·Amber R Cordola HsuNathan D Wong
Sep 17, 2019·The Journal of Clinical Investigation·Gordon I SmithSamuel Klein
Feb 6, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Luna LiuQingbo Guan
Dec 29, 2020·International Journal of Epidemiology·Ming ZhangDongsheng Hu
May 12, 2021·Journal of Gastroenterology and Hepatology·Tsung-Po ChenKuen-Cheh Yang
Jun 8, 2021·The Lancet. Diabetes & Endocrinology·Youfa WangHong Xue
Jun 18, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Jie MinLulu Chen
Aug 14, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Xiaoyue ZhuBei Wang

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