PMID: 1194160Oct 1, 1975Paper

Dynamic stiffness profiles in the left ventricle

Journal of Applied Physiology
A KennishR W Frater

Abstract

Diastolic pressure-volume (P-V) curves were calculated on a beat-to-beat basis in the open-chest, pentobarbital-anesthetized dog, using the technique of direct transmitral flow measurement previously described. P-V curves were constructed and the slope (dP/dV) was plotted vs. pressure and time. dP/dV was used as an index of stiffness in each heart and its instantaneous changes with time were followed throughout the diastolic period. The end-diastolic P-V relation based on points from successive cycles during volume loading was found to be exponential. In contrast, the instantaneous P-V relation during any one diastolic period was not exponential. That is, the dynamic dP/dV vs. pressure plot was nonlinear. In the normal heart, stiffness was characterized in early diastole by a negative dP/dV as the ventricle continued to relax, and then frequently decreased prior to a second stiffness rise with atrial augmentation. These findings can be explained by a model containing an element whose deformation is rate dependent, i.e., a parallel viscous element. Stiffness profiles in mitral stenosis where dynamic effects are minimized substantiate this conclusion.

Citations

Jun 1, 1986·Circulation·T MurakamiH P Krayenbuehl
Aug 1, 1990·Circulation Research·S D NikolicE L Yellin
Dec 22, 2019·Bioengineering·Wenqiang Liu, Zhijie Wang
Jul 1, 1977·Circulation Research·J S RankinR W Anderson
Feb 1, 1978·Circulation Research·S A Glantz, W W Parmley
Feb 15, 2005·Biomedical Engineering Online·Liang ZhongSoo T Lim
Nov 25, 2011·Experimental Biology and Medicine·Miguel GuerraAdelino F Leite-Moreira
Dec 28, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·B Z AtkinsD A Taylor

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