Dynamic study of interaction between beta-cyclodextrin and aspirin by the ultrasonic relaxation method

The Journal of Physical Chemistry. B
Takanori FukahoriSadakatsu Nishikawa

Abstract

A single ultrasonic relaxational phenomenon was observed in aqueous solutions containing both beta-cyclodextrin (beta-CD) as host and nonionized or ionized acetylsalicylic acid (aspirin) as guest. The observed relaxation was responsible for a dynamic complexation reaction between beta-CD and aspirin molecules, concomitant with a volume change during the reaction. The kinetic and equilibrium constants for the complexation in the acid (nonionized) form of the aspirin system were derived from the guest concentration dependence of the relaxation frequency. The equilibrium constant for the carboxylate (ionized) form of aspirin was determined from the concentration dependence of a maximum absorption per wavelength, and the rate constants were calculated by using the determined equilibrium constant and the observed relaxation frequencies, which remained nearly almost constant over the concentration range studied. The results showed that the effect of charge on the aspirin molecule was reflected only in the dissociation process from the beta-CD cavity, while no remarkable change was seen in the association process whose rate was diffusion controlled. The results could be explained on the basis of the difference of the hydrophobic moiet...Continue Reading

References

Jan 1, 1968·Journal of Pharmaceutical Sciences·T F ChinJ L Lach
Mar 21, 2000·International Journal of Pharmaceutics·I T SomeJ Dubois
Jun 6, 2000·Advanced Drug Delivery Reviews·V J StellaV Zia
Aug 5, 1997·Chemical Reviews·Kenneth A. Connors
May 14, 2004·The Journal of the Acoustical Society of America·Takanori FukahoriKyohei Yamaguchi
Jul 15, 2006·The Journal of Physical Chemistry. a·Kyohei YamaguchiSadakatsu Nishikawa

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Citations

Dec 3, 2010·Journal of Colloid and Interface Science·Rachel T Rosenberg, Nily R Dan
Jun 29, 2010·Journal of Colloid and Interface Science·Rachel T Rosenberg, Nily R Dan
Jan 28, 2009·The Journal of Physical Chemistry. B·Julian Haller, Udo Kaatze
Dec 29, 2010·The Journal of Physical Chemistry. a·Sadakatsu Nishikawa, Eri Kamimura
Jun 25, 2020·Journal of Chemical Theory and Computation·Benjamin R JaggerRommie E Amaro
Feb 28, 2019·Journal of Chemical Theory and Computation·Wanli YouChia-En A Chang
Aug 7, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Doreen NietherSimone Wiegand
Nov 2, 2007·The Journal of Physical Chemistry. B·Minako Kondo, Sadakatsu Nishikawa
Oct 18, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Cornelia Bohne

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