Dynamic surveillance of SARS-CoV-2 shedding and neutralizing antibody in children with COVID-19.

Emerging Microbes & Infections
Pengcheng LiuJin Xu

Abstract

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China and quickly spread globally. In this study, we investigated the characteristics of viral shedding from different sites and the neutralizing antibody (NAb) response during the acute and convalescent phases of nine children with COVID-19. SARS-CoV-2 was detected in their nasopharyngeal swabs (9/9, 100%), stool samples (8/9, 89%), and oropharyngeal swabs (3/9, 33%) but was not detected in their serum and urine samples. The median duration of viral shedding detected in nasopharyngeal swabs, oropharyngeal swabs, and stools was 13, 4, and 43 days respectively, and the maximum duration of viral shedding detected from stools was 46 days after discharge. In children, nasopharyngeal swabs appear to be a more sensitive specimen type for the diagnosis of COVID-19 compared with oropharyngeal swabs. Three of eight patients produced NAbs in the acute phase, and NAbs were detected in all eight patients with convalescent sera. The results of this study provide valuable information for the diagnosis and surveillance of COVID-19 and development of SARS-CoV-2 vaccines for use in children.

References

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Citations

Jun 26, 2020·The Cochrane Database of Systematic Reviews·Jonathan J DeeksUNKNOWN Cochrane COVID-19 Diagnostic Test Accuracy Group
Jun 24, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Daniela BassoMario Plebani
Jun 9, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ferric C FangAlexander L Greninger
Aug 30, 2020·Annals of the New York Academy of Sciences·Elizabeth Centeno-TablanteSaurabh Mehta
Aug 28, 2020·Alimentary Pharmacology & Therapeutics·Amarylle S van DoornNanne K H de Boer
Aug 30, 2020·The Indian Journal of Medical Research·Gururaj Rao DeshpandeUNKNOWN COVID Support Team
Sep 24, 2020·Pediatric Pulmonology·Evanthia PerikleousEmmanouil Paraskakis
Nov 19, 2020·Transboundary and Emerging Diseases·Fangfeng YuanLeyi Wang
Jan 1, 2021·PloS One·Nathan PostSharif A Ismail
Jan 8, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Giada Maria Di PietroUNKNOWN Testing Pediatric Covid-19 (TPC-19)
Dec 12, 2020·Frontiers in Pediatrics·Marketa BloomfieldMartin Magner
Feb 17, 2021·Nature Reviews. Gastroenterology & Hepatology·Meng GuoShu Zhu
Feb 22, 2021·The Science of the Total Environment·Alexandre GiacobboMaria Norberta de Pinho
Mar 23, 2021·Frontiers in Pediatrics·Xuejiao HanXiawei Wei
May 5, 2021·Journal of Clinical Immunology·Pandiarajan VigneshMan Updesh Singh Sachdeva
May 4, 2021·Frontiers in Immunology·Mateo Chvatal-MedinaMaria T Rugeles
Aug 27, 2021·Signal Transduction and Targeted Therapy·Zirui MengBinwu Ying
Sep 17, 2021·Journal of Clinical Immunology·Madhu Chhanda MohantyVarsha Potdar

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