Dynamic Synthetic Biointerfaces: From Reversible Chemical Interactions to Tunable Biological Effects

Accounts of Chemical Research
Yue MaGuoqing Pan

Abstract

Dynamic synthetic biointerface is a new concept of biomaterials with smart surface properties capable of controlled display of bioactive ligands, dynamic modulation of cell-biomaterial interactions, and subsequently clever manipulation of fundamental cell behaviors like adhesion, migration, proliferation, differentiation, apoptosis, and so on. As mimics of the extracellular matrix (ECM), such molecularly dynamic biointerfaces have attracted increasing attention because of their tunable biological effects with great significance in in situ cell biology, tissue engineering, drug targeting, and cell isolation for cancer theranostics. Approaches to control bioligand presentation on materials mainly rely on surface functionalization with dynamic or reversible chemical linkers to which the ligands are tethered. Photoelectric-transformable or photocleavable chemistry, host-guest supramolecular chemistry, and multiple noncovalent interactions were initially employed for fabrication of dynamic synthetic biointerfaces. However, the external stimuli required in these systems, including electrochemical potential, electrochemical reaction, and near-infrared or UV light, are mostly invasive to living cells; and few of them are able to respon...Continue Reading

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Citations

Jul 18, 2020·Research : a Science Partner Journal·Yu XiaoZhilu Yang
Nov 24, 2020·Macromolecular Rapid Communications·Xiaoming XieWen Li
Apr 20, 2021·Research : a Science Partner Journal·Yue MaGuoqing Pan
Jul 9, 2021·Acta Biomaterialia·Xingzhen Zhang, Sabine van Rijt
Oct 15, 2019·ACS Applied Materials & Interfaces·Xiaohua TianGuoqing Pan
Aug 17, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Enrique Sanchez PerezLiliane Coche-Guérente
Mar 11, 2020·ACS Applied Materials & Interfaces·Dainelys Guadarrama BelloAntonio Nanci
Jan 15, 2020·ACS Applied Materials & Interfaces·Yang ZhouHong Chen
Dec 10, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Fenghua WangLei Liu

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