Dynamic taste responses of parabrachial pontine neurons in awake rats

Journal of Neurophysiology
Madelyn A Baez-SantiagoDonald B Katz

Abstract

The parabrachial nuclei of the pons (PbN) receive almost direct input from taste buds on the tongue and control basic taste-driven behaviors. Thus it is reasonable to hypothesize that PbN neurons might respond to tastes in a manner similar to that of peripheral receptors, i.e., that these responses might be narrow and relatively "dynamics free." On the other hand, the majority of the input to PbN descends from forebrain regions such as gustatory cortex (GC), which processes tastes with "temporal codes" in which firing reflects first the presence, then the identity, and finally the desirability of the stimulus. Therefore a reasonable alternative hypothesis is that PbN responses might be dominated by dynamics similar to those observed in GC. Here we examined simultaneously recorded single-neuron PbN (and GC) responses in awake rats receiving exposure to basic taste stimuli. We found that pontine taste responses were almost entirely confined to canonically identified taste-PbN (t-PbN). Taste-specificity was found, furthermore, to be time varying in a larger percentage of these t-PbN responses than in responses recorded from the tissue around PbN (including non-taste-PbN). Finally, these time-varying properties were a good match fo...Continue Reading

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Feb 2, 2020·Cellular and Molecular Life Sciences : CMLS·Ranier GutierrezSidney A Simon
Feb 29, 2020·Experimental Biology and Medicine·Stephanie M StaszkoMax L Fletcher
Nov 19, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christopher J HaddockGina L C Yosten
Apr 29, 2021·Journal of Neurophysiology·Louis J MartinSuzanne I Sollars
Aug 31, 2021·Neuropharmacology·A A JaramilloD G Winder

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