Dynamic testing with high-dose adrenocorticotrophic hormone does not improve lateralization of aldosterone oversecretion in primary aldosteronism patients

Journal of Hypertension
Gian Paolo RossiAchille C Pessina

Abstract

Diagnosing aldosterone-producing adenoma (APA) involves a demonstration of the lateralization of aldosterone oversecretion because adrenal incidentalomas are common in hypertensive individuals and many small-sized APA escape identification with available imaging techniques. However, because of the pulsatile pattern of aldosterone secretion this can be a difficult undertaking. Stimulation of aldosterone secretion before adrenal vein sampling (AVS) can overcome this difficulty, but anecdotal data exist. We, therefore, prospectively investigated the usefulness of AVS with dynamic testing in primary aldosteronism (PA) patients. We enrolled 24 consecutive consenting patients with a biochemical diagnosis of PA from a tertiary referral centre to measure the effects of adrenocorticotrophic hormone (ACTH) on selectivity, the lateralization of aldosterone secretion to the APA side, and adverse effects. After correcting the hypokalemia we performed bilateral AVS. After 3 h supine resting, blood was simultaneously obtained from both sides. A high-dose ACTH (250 mug intravenous) bolus was then administered and AVS was repeated after 30 min. AVS was bilaterally selective in 88% of patients; no adverse effects occurred. Of the 21 patients wit...Continue Reading

Associated Clinical Trials

Feb 28, 2018·Gian Paolo Rossi, MD, FAHA, FACC

References

Mar 1, 1979·Annals of Internal Medicine·M H WeinbergerJ P Donohue
Feb 19, 1976·The New England Journal of Medicine·M J HoganE G Biglieri
Nov 1, 1973·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·H A MittyJ L Gabrilove
Jun 1, 1972·Annals of Internal Medicine·B A ScogginsJ P Coghlan
Jun 1, 1972·Annals of Internal Medicine·G L NicolisJ L Gabrilove
Aug 1, 1970·The British Journal of Radiology·R I BaylissF Starer
Feb 1, 1969·Archives of Internal Medicine·J W Conn
Nov 16, 1967·The New England Journal of Medicine·J C MelbyP C Kahn
Aug 1, 1983·AJR. American Journal of Roentgenology·M A GeisingerG P Borkowski
May 1, 1993·Clinical and Experimental Pharmacology & Physiology·R D GordonS A Klemm
Sep 27, 1993·Archives of Internal Medicine·M H Weinberger, N S Fineberg
Feb 1, 1996·Radiology·J L Doppman, J R Gill
Jan 1, 1997·Hormone Research·B Allolio, M Reincke
Apr 21, 1999·Clinical Endocrinology·G P RossiA C Pessina
Sep 18, 2002·Circulation·John H RundbackUNKNOWN AHA Councils on Cardiovascular Radiology, High Blood Pressure Research, Kidney in Cardiovascular Disease, Cardio-Thoracic an
Dec 7, 2002·Hypertension·Paolo MulateroFranco Veglio
Aug 14, 2003·The Journal of Clinical Endocrinology and Metabolism·E A EspinerP J Hunt
Nov 29, 1957·Acta Medica Scandinavica·A MASONI
Feb 20, 2004·Current Hypertension Reports·Gian Paolo Rossi
May 12, 2004·Molecular and Cellular Endocrinology·Mary H BassettWilliam E Rainey
Jan 20, 2005·Surgery·William F YoungJon A van Heerden
Jun 30, 2005·The Journal of Clinical Endocrinology and Metabolism·Mary H BassettWilliam E Rainey

❮ Previous
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Citations

Oct 2, 2009·Cardiovascular and Interventional Radiology·Miroslav SolarJan Cap
Feb 3, 2011·Reviews in Endocrine & Metabolic Disorders·Richard J Auchus
Mar 4, 2011·Reviews in Endocrine & Metabolic Disorders·Gian Paolo D Rossi
Jul 29, 2010·Current Hypertension Reports·Gian Paolo Rossi
Nov 2, 2011·Endocrine·Norlela Sukor
May 21, 2010·Orphanet Journal of Rare Diseases·Laurence AmarOlivier Steichen
Feb 6, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Fumitoshi SatohSadayoshi Ito
Dec 4, 2008·European Journal of Endocrinology·Masayuki TanemotoSadayoshi Ito
Jun 11, 2008·Clinical and Experimental Nephrology·Kenji OkiNobuoki Kohno
Apr 2, 2013·Journal of Vascular and Interventional Radiology : JVIR·Mark BurshteynScott O Trerotola
Sep 20, 2011·European Journal of Internal Medicine·Norlela Sukor
May 14, 2011·Endocrinology and Metabolism Clinics of North America·Gian Paolo Rossi
Jun 15, 2010·Techniques in Vascular and Interventional Radiology·S Lowell Kahn, J Fritz Angle
Mar 4, 2008·Trends in Endocrinology and Metabolism : TEM·Gilberta GiacchettiFrancesco Fallo
Jan 9, 2009·Clinical Endocrinology·William F Young, Anthony W Stanson
May 12, 2007·Clinical Endocrinology·William F Young
Sep 19, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·Gian Paolo Rossi
Dec 13, 2006·Journal of the American College of Cardiology·Gian Paolo RossiUNKNOWN PAPY Study Investigators
Apr 23, 2013·Clinical Biochemistry·Panda Elliott, Daniel T Holmes
Feb 22, 2017·Endocrine Regulations·F A FarrugiaA Charalampopoulos
Jan 12, 2017·Japanese Journal of Radiology·Yuya KoikeTetsuo Nishikawa
Mar 18, 2017·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Maurizio CesariGian Paolo Rossi
Mar 10, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Gian Paolo Rossi
Aug 9, 2017·Clinical Endocrinology·Aya T NanbaAdina F Turcu
Sep 13, 2017·Journal of Clinical Pathology·Gregory Kline, Daniel T Holmes
May 26, 2011·Nature Reviews. Endocrinology·Gian Paolo Rossi
Jun 27, 2007·Hypertension·Gian Paolo RossiUNKNOWN Primary Aldosteronism Prevalence in Italy Study Investigators
Jul 19, 2018·Journal of Hypertension·Hiroki KobayashiUNKNOWN JPAS Study Group
Aug 5, 2015·Hypertension·Francesca GiocoCelso E Gomez-Sanchez
Nov 26, 2009·Hypertension·Gian Paolo RossiUNKNOWN Primary Aldosteronism in the Prevalence in hYpertension (PAPY) Study Investigators
Jan 11, 2007·Journal of Hypertension·Masayuki TanemotoSadayoshi Ito
Jun 15, 2007·Journal of Hypertension·Gian Paolo RossiUNKNOWN PAPY Study Investigators
Mar 1, 2008·Clinical and Experimental Pharmacology & Physiology·Pierre-François PlouinLaurence Amar
Aug 14, 2008·Journal of Hypertension·Emmanuel LetavernierPierre-François Plouin
Jun 17, 2008·The Journal of Clinical Endocrinology and Metabolism·John W FunderUNKNOWN Endocrine Society
May 3, 2007·The Journal of Clinical Endocrinology and Metabolism·Richard J AuchusRonald G Victor

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