Dynamic tuning of DNA-nanoparticle superlattices by molecular intercalation of double helix

Journal of the American Chemical Society
Suchetan PalOleg Gang

Abstract

Nanoparticle (NP) assembly using DNA recognition has emerged as a powerful tool for the fabrication of 3D superlattices. In addition to the vast structural diversity, this approach provides an avenue for dynamic 3D NP assembly, which is promising for the modulation of interparticle distances and, hence, for example, for in situ tuning of optical properties. While several approaches have been explored for changing NP separations in the lattices using responsiveness of single-stranded DNA (ss-DNA), far less work has been done for the manipulation of most abundant double-stranded DNA (ds-DNA) motifs. Here, we present a novel strategy for modulation of interparticle distances in DNA linked 3D self-assembled NP lattices by molecular intercalator. We utilize ethidium bromide (EtBr) as a model intercalator to demonstrate selective and isotropic lattice expansion for three superlattice types (bcc, fcc, and AlB2) due to the intercalation of ds-DNA linking NPs. We further show the reversibility of the lattice parameter using n-butanol as a retrieving agent as well as an increased lattice thermal stability by 12-14 °C due to the inclusion of EtBr. The proposed intercalator-based strategy permits the creation of reconfigurable and thermall...Continue Reading

References

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Citations

Dec 25, 2015·ACS Nano·Soyoung E SeoChad A Mirkin
Mar 15, 2016·Journal of Photochemistry and Photobiology. B, Biology·Mullah Muhaiminul IslamSivaprasad Mitra
Apr 18, 2016·Nucleic Acids Research·Ali A AlmaqwashiMark C Williams
Jul 19, 2016·Nano Letters·Stacey N BarnabyChad A Mirkin
Jul 13, 2016·Journal of the American Chemical Society·Jarad A MasonChad A Mirkin
Jan 26, 2017·Journal of the American Chemical Society·Janet R McMillanChad A Mirkin
Mar 25, 2016·Chemical Communications : Chem Comm·Brian J CaffertyNicholas V Hud
Jan 17, 2020·Advanced Materials·Jinghan ZhuChad A Mirkin
Mar 2, 2021·ACS Applied Materials & Interfaces·Joshua M KubiakRobert J Macfarlane
Feb 6, 2020·Current Opinion in Biotechnology·Jason S KahnOleg Gang
Apr 27, 2021·Advanced Science·Liangcan HeXiaoyuan Chen
Jul 25, 2021·International Journal of Molecular Sciences·Shuang WangYe Tian
Apr 7, 2018·Journal of the American Chemical Society·Jinghan ZhuChad A Mirkin
Feb 6, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Michael J Solomon
Nov 28, 2018·ACS Applied Materials & Interfaces·Na LiBaoquan Ding
Jan 25, 2017·ACS Nano·Mary X WangChad A Mirkin
Jun 16, 2021·Angewandte Chemie·Jason S Kahn, Oleg Gang

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