PMID: 8977656Jul 1, 1996Paper

Dynamic unconfined compression of articular cartilage under a cyclic compressive load

Biorheology
J K Suh

Abstract

To study the effect of dynamic mechanical force on cartilage metabolism, many investigators have applied a cyclic compressive load to cartilage disc explants in vitro. The most frequently used in vitro testing protocol has been the cyclic unconfined compression of articular cartilage in a bath of culture medium. Cyclic compression has been achieved by applying either a prescribed cyclic displacement or a prescribed cyclic force on a loading platen placed on the top surface of a cylindrical cartilage disc. It was found that the separation of the loading platen from the tissue surface was likely when a prescribed cyclic displacement was applied at a high frequency. The purpose of the present study was to simulate mathematically the dynamic behavior of a cylindrical cartilage disc subjected to cyclic unconfined compression under a dynamic force boundary condition protocol, and to provide a parametric analysis of mechanical deformations within the extracellular matrix. The frequency-dependent dynamic characteristics of dilatation, hydrostatic pressure and interstitial fluid velocity were analyzed over a wide range of loading frequencies without the separation of the loading platen. The result predicted that a cyclic compressive for...Continue Reading

Citations

Jun 29, 2010·Biomechanics and Modeling in Mechanobiology·A Félix QuiñonezZ M Jin
Mar 11, 2003·Tissue Engineering·Eric M Darling, Kyriacos A Athanasiou
Jun 3, 2004·Journal of Biomechanical Engineering·Bram G SengersFrank P Baaijens
Aug 5, 2010·Journal of Tissue Engineering and Regenerative Medicine·Arzu TasciPhilippe Büchler
Jun 17, 2005·Journal of Biomechanics·Ramaswamy KrishnanGerard A Ateshian
Jan 7, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M J KääbH P Nötzli

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