Dynamically decreased miR-671-5p expression is associated with oncogenic transformation and radiochemoresistance in breast cancer

Breast Cancer Research : BCR
Xiaohui TanSidney W Fu

Abstract

Understanding the molecular alterations associated with breast cancer (BC) progression may lead to more effective strategies for both prevention and management. The current model of BC progression suggests a linear, multistep process from normal epithelial to atypical ductal hyperplasia (ADH), to ductal carcinoma in situ (DCIS), and then invasive ductal carcinoma (IDC). Up to 20% ADH and 40% DCIS lesions progress to invasive BC if left untreated. Deciphering the molecular mechanisms during BC progression is therefore crucial to prevent over- or under-treatment. Our previous work demonstrated that miR-671-5p serves as a tumor suppressor by targeting Forkhead box protein M1 (FOXM1)-mediated epithelial-to-mesenchymal transition (EMT) in BC. Here, we aim to explore the role of miR-671-5p in the progression of BC oncogenic transformation and treatment. The 21T series cell lines, which were originally derived from the same patient with metastatic BC, including normal epithelia (H16N2), ADH (21PT), primary DCIS (21NT), and cells derived from pleural effusion of lung metastasis (21MT), and human BC specimens were used. Microdissection, miRNA transfection, dual-luciferase, radio- and chemosensitivity, and host-cell reactivation (HCR) as...Continue Reading

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Citations

Jul 17, 2020·Non-coding RNA·Jun Sheng Wong, Yoke Kqueen Cheah
Jan 7, 2021·Biotechnology Letters·Qiushi WangZhengang Zha
Dec 29, 2020·International Journal of Radiation Biology·Zhi Xiong ChongWan Yong Ho
Jan 11, 2021·Pathology, Research and Practice·Kaveh EbahimzadehSoudeh Ghafouri-Fard
Mar 9, 2021·Frontiers in Oncology·Dhanya KalathilAsha S Nair
Jul 23, 2021·The Kaohsiung Journal of Medical Sciences·Wan-Ju WangFang Liu

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Methods Mentioned

BETA
biopsy
reverse transcription-PCR
Transfection
Assay
transfections

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