Dynamics and consequences of IL-21 production in HIV-infected individuals: a longitudinal and cross-sectional study

The Journal of Immunology : Official Journal of the American Association of Immunologists
Alexandre IannelloAli Ahmad

Abstract

IL-21 is a relatively newly discovered immune-enhancing cytokine that plays an essential role in controlling chronic viral infections. It is produced mainly by CD4(+) T cells, which are also the main targets of HIV-1 and are often depleted in HIV-infected individuals. Therefore, we sought to determine the dynamics of IL-21 production and its potential consequences for the survival of CD4(+) T cells and frequencies of HIV-specific CTL. For this purpose, we conducted a series of cross-sectional and longitudinal studies on different groups of HIV-infected patients and show in this study that the cytokine production is compromised early in the course of the infection. The serum cytokine concentrations correlate with CD4(+) T cell counts in the infected persons. Among different groups of HIV-infected individuals, only elite controllers maintain normal production of the cytokine. Highly active antiretroviral therapy only partially restores the production of this cytokine. Interestingly, HIV infection of human CD4(+) T cells inhibits cytokine production by decreasing the expression of c-Maf in virus-infected cells, not in uninfected bystander cells. We also show that the frequencies of IL-21-producing HIV-specific, but not human CMV-s...Continue Reading

References

Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·J EstaquierJ C Ameisen
Jun 1, 1993·Seminars in Immunology·G PantaleoA S Fauci
Dec 10, 1998·Immunity·G M Shearer
Jul 6, 2000·The Journal of Experimental Medicine·V AppayS L Rowland-Jones
May 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mari StrengellTimo Sareneva
Aug 2, 2003·Blood·Katja BrandtRené Rückert
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martin PelletierDenis Girard
Jan 5, 2005·The Journal of Experimental Medicine·Rong ZengWarren J Leonard
Aug 11, 2005·Current HIV/AIDS Reports·Abeer MoannaGuido Silvestri
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rachel EttingerPeter E Lipsky
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ilaria PelusoGiovanni Monteleone
Feb 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Lia VassenaPaolo Lusso
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rachel EttingerPeter E Lipsky
Jun 8, 2007·Journal of Leukocyte Biology·Valérie OstiguyNathalie Labrecque
Sep 22, 2007·The Journal of Biological Chemistry·Lai WeiJohn J O'Shea
Oct 24, 2007·Annual Review of Immunology·Rosanne Spolski, Warren J Leonard
Feb 9, 2008·Nature Reviews. Drug Discovery·Kresten SkakPallavur V Sivakumar
Apr 18, 2008·Cytokine·Danylo SirskyjMarko Kryworuchko
May 14, 2008·The Journal of Experimental Medicine·Akira SutoHiroshi Nakajima
Aug 13, 2008·Expert Opinion on Biological Therapy·David J Andorsky, John M Timmerman
Sep 12, 2008·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Victor AppayMario Roederer
Jan 10, 2009·Annual Review of Immunology·Thomas KornVijay K Kuchroo
Mar 17, 2009·The Journal of Clinical Investigation·Yves LevyJean-François Delfraissy
May 9, 2009·Science·Heidi ElsaesserDavid G Brooks

❮ Previous
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Citations

Aug 21, 2010·Immunologic Research·Elizabeth B Wilson, David G Brooks
Apr 20, 2011·Current Opinion in HIV and AIDS·Filippos Porichis, Daniel E Kaufmann
Apr 13, 2011·Clinical Microbiology Reviews·Candice K Kwan, Joel D Ernst
Dec 17, 2010·Journal of Virology·LaTonya D WilliamsPaul A Goepfert
Sep 20, 2011·The Journal of Clinical Investigation·Julien van GrevenyngheElias K Haddad
Jun 10, 2011·Blood·Filippos PorichisDaniel E Kaufmann
Feb 17, 2011·Immunotherapy·June Myung Kim, Sang Hoon Han
Jun 14, 2013·Clinical & Developmental Immunology·Sandra L Bixler, Joseph J Mattapallil
Apr 23, 2014·Nature Reviews. Drug Discovery·Rosanne Spolski, Warren J Leonard
Nov 30, 2013·Viruses·Patrick YounanHans-Peter Kiem
Mar 10, 2016·Annual Review of Virology·Elina I ZunigaJames A Harker
May 12, 2015·Journal of Immunology Research·Michela CroceSilvano Ferrini
Apr 6, 2017·Medical Microbiology and Immunology·Taraneh RajaeiSeyed Abdolrahim Rezaee
Feb 2, 2018·The Journal of Infectious Diseases·Padmaja PaidipallyRamakrishna Vankayalapati
Mar 6, 2016·Journal of the International AIDS Society·Wei CaoJean-Pierre Routy
Dec 2, 2017·Applied Biochemistry and Biotechnology·Halla Mohamed RagabShorouk M Moussa
Nov 16, 2017·AIDS Research and Human Retroviruses·Gema Méndez-LagaresDennis J Hartigan-O'Connor
Mar 12, 2016·F1000Research·Warren J Leonard, Chi-Keung Wan
Mar 6, 2010·Immunology·John S YiAllan J Zajac
Jun 26, 2015·Nature Communications·Stanley AdoroLaurie H Glimcher
May 23, 2019·Mucosal Immunology·Félicien MoukambiJérôme Estaquier
Apr 28, 2012·European Journal of Immunology·Melanie Wiesel, Annette Oxenius
Jul 16, 2013·Cellular and Molecular Life Sciences : CMLS·Julie Tellier, Stephen L Nutt
Aug 3, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Guohua FengFu-Sheng Wang
Mar 29, 2014·Experimental and Therapeutic Medicine·Hong-Mei ChenYing-Ren Zhao
Apr 17, 2014·Journal of Leukocyte Biology·Georgina ThorbornGeorge Kassiotis
Dec 8, 2015·PLoS Pathogens·Félicien MoukambiJérôme Estaquier

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