Aug 8, 2016

Dynamics and fate of beneficial mutations under lineage contamination by linked deleterious mutations

BioRxiv : the Preprint Server for Biology
Sophie PénissonPhilip Gerrish


As mutation rate increases, the corresponding increase in numbers of adaptive variants ought to lead to increasingly fierce competition and faster adaptation. Here we find, however, that the intensity of competition does not increase monotonically with mutation rate but instead can decrease at high mutation rates because of linked deleterious mutations. Owing to stochastic sampling effects, newly-arising adaptive mutations will become burdened with new deleterious mutations at a rate that is, on average, higher than the rest of the population. At high mutation rates, this effect can alleviate competition among adaptive mutations, or even shut down the adaptive process.

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Mutation Abnormality
Population Group

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