May 23, 2018

Dynamics and function of DNA methylation in plants

Nature Reviews. Molecular Cell Biology
Huiming ZhangJian-Kang Zhu

Abstract

DNA methylation is a conserved epigenetic modification that is important for gene regulation and genome stability. Aberrant patterns of DNA methylation can lead to plant developmental abnormalities. A specific DNA methylation state is an outcome of dynamic regulation by de novo methylation, maintenance of methylation and active demethylation, which are catalysed by various enzymes that are targeted by distinct regulatory pathways. In this Review, we discuss DNA methylation in plants, including methylating and demethylating enzymes and regulatory factors, and the coordination of methylation and demethylation activities by a so-called methylstat mechanism; the functions of DNA methylation in regulating transposon silencing, gene expression and chromosome interactions; the roles of DNA methylation in plant development; and the involvement of DNA methylation in plant responses to biotic and abiotic stress conditions.

Mentioned in this Paper

Biochemical Pathway
DNA Methylation [PE]
Protein Methylation
Enzymes, antithrombotic
Regulation of Biological Process
Cellular Response to Abiotic Stimulus
Genomic Stability
DNA Methylation
Gene Expression Regulation, Plant
Regulation of Gene Silencing

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