Dynamics and functions of CD4⁺CD25 (high) regulatory T lymphocytes in Chinese rhesus macaques during the early stage of infection with SIVmac239

Archives of Virology
Shao-You LiYong-Tang Zheng

Abstract

CD4(+)CD25(high) regulatory T cells (Treg), which are a specialized subset of T cells, play an important role in the prevention of autoimmune diseases, maintenance of immune system homeostasis and tolerance to self-antigens. Chinese rhesus macaques (CRMs) are widely used in preclinical research on potential therapeutic drugs, vaccines and mechanisms of human diseases. However, the basic immunological characterization of Treg cells of CRMs has not been well established. To characterize Treg cells, peripheral blood of 43 adult CRMs was analyzed for CD4+ T lymphocytes by flow cytometry. It was found that Treg cells ranged from 1.52% to 11.1% of CD4+ T cells, and the average value was 5.7%. With our SIV-infected CRM model, through further studies, it was found that Treg cells in peripheral blood increased both in relative and absolute quantities. Moreover, Treg cells maintained their functions by suppressing Th1 cytokine secretion of their target cells. The results show that Treg cells might render cellular immunity against SIV viruses dysfunctional during the early stage after infection.

References

Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C Baecher-AllanD A Hafler
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luis GracaHerman Waldmann
Jul 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ludger KleinHarald von Boehmer
Sep 17, 2003·The Journal of Experimental Medicine·Susmit SuvasBarry T Rouse
Apr 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steven J BensingerLaurence A Turka
Jul 15, 2004·PLoS Biology·Kyra Oswald-RichterDerya Unutmaz
Nov 3, 2004·International Immunology·Zoltán Fehérvári, Shimon Sakaguchi
Mar 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark P EggenaHuyen Cao
May 17, 2005·Microbes and Infection·Douglas F NixonJakob Michaëlsson
Jul 5, 2006·The Journal of Experimental Medicine·Nabila SeddikiBarbara Fazekas de St Groth
Jul 5, 2006·The Journal of Experimental Medicine·Weihong LiuJeffrey A Bluestone
Aug 15, 2006·Immunological Reviews·Maria Grazia RoncaroloMegan K Levings
Aug 15, 2006·Immunological Reviews·Ethan M ShevachAngela M Thornton
Aug 15, 2006·Immunological Reviews·Karsten KretschmerHarald von Boehmer
Aug 15, 2006·Immunological Reviews·Clare Baecher-Allan, David A Hafler
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kazuki HiraharaThomas S Kupper
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guglielmo M VenturiThomas F Tedder
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura StraussAlfred Zippelius
Jul 2, 2009·Cellular & Molecular Immunology·Houjun XiaYongtang Zheng

❮ Previous
Next ❯

Citations

Nov 17, 2015·Journal of Immunology Research·Jacqueline María Valverde-VillegasJosé Artur Bogo Chies

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.