Aug 16, 2016

Dynamics and Molecular Mechanisms of Ventricular Fibrillation in Structurally Normal Hearts

Cardiac Electrophysiology Clinics
J Jalife

Abstract

Ventricular fibrillation (VF) is the most severe cardiac rhythm disturbance and one of the most important immediate causes of sudden cardiac death. In the structurally normal heart, a small number of stable reentrant sources, perhaps 1 or 2, underlie the mechanism of VF, and the stabilization of the sources, their frequency, and the complexity of the turbulent waves they generate depend on the expression, spatial distribution, and intermolecular interactions of the 2 most important ion channels that control cardiac excitability: the inward rectifier potassium channel, Kir2.1, and the alpha subunit of the main cardiac sodium channel, NaV1.5.

  • References34
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Citations

Mentioned in this Paper

KCNJ2 gene
Ventricular Fibrillation
NAV1.3 Voltage-Gated Sodium Channel
Spatial Distribution
SCN5A gene
Sleep Disorders, Circadian Rhythm
Ion Channel
Cardiac Rhythm Type
Inward rectifier potassium channel
Cardiac Conduction System

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