Dynamics and organization of MAP kinase signal pathways

Molecular Reproduction and Development
B ErredeK Matsumoto

Abstract

In the budding yeast, Saccharomyces cerevisiae, four separate but structurally related mitogen-activated protein kinase (MAPK) activation pathways are known. The best understood of these regulates mating. Pheromone binding to receptor informs cells of the proximity of a mating partner and induces differentiation to a mating competent state. The MAPK activation cascade mediating this signal is made up of Ste11 (a MEK kinase [MEKK]), Ste7 (a MAPK/ERK kinase [MEK]), and the redundant MAPK-related Fus3 and Kss1 enzymes. Another MAPK activation pathway is important for cell integrity and regulates cell wall construction. This cascade consists of Bck1 (a MEKK), the redundant Mkk1 and Mkk2 enzymes (MEKs), and Mpk1 (a MAPK). We exploited these two pathways to learn about the coordination and signal transmission fidelity of MAPK activation cascades. Two lines of evidence suggest that the activities of the mating and cell integrity pathways are coordinated during mating differentiation. First, cells deficient in Mpk1 are susceptible to lysis when they make a mating projection in response to pheromone. Second, Mpk1 activation during pheromone induction coincides with projection formation. The mechanism underlying this coordination is stil...Continue Reading

References

Mar 1, 1992·The Journal of Cell Biology·D E Levin, E Bartlett-Heubusch
Jan 1, 1988·Annual Review of Cell Biology·F CrossJ B Konopka
Apr 1, 1995·Current Opinion in Cell Biology·D E Levin, B Errede
Nov 1, 1994·Molecular Biology of the Cell·J Chenevert
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·S MarcusM Wigler
Feb 1, 1994·Current Opinion in Genetics & Development·C J Marshall
Feb 1, 1994·Current Opinion in Genetics & Development·G Ammerer
Apr 1, 1993·Current Opinion in Cell Biology·B Errede, D E Levin

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Citations

Jan 3, 2001·Teratogenesis, Carcinogenesis, and Mutagenesis·F OzawaM W Büchler
Feb 9, 2013·Bulletin of Mathematical Biology·A ZakharovaA Koseska
Apr 1, 1995·Current Opinion in Cell Biology·D E Levin, B Errede
Aug 8, 2002·FEMS Microbiology Reviews·Frans M KlisStanley Brul
Nov 2, 2002·Molecular Microbiology·Un Sung JungDavid E Levin
Oct 10, 2008·The Journal of Biological Chemistry·Lilia R NunezSusan A Henry
Feb 1, 1997·Molecular Biology of the Cell·J L WitheeM S Cyert
Jun 17, 1998·Molecular Biology of the Cell·A E GammieM D Rose
Jun 2, 2006·Molecular Biology of the Cell·Nan-Nan ZhangKyle W Cunningham
Apr 25, 2013·Science Signaling·Rodrigo BaltanásAlejandro Colman-Lerner
Dec 14, 2004·Eukaryotic Cell·Hui JinEric Grote
Jun 1, 2002·Microbiology and Molecular Biology Reviews : MMBR·Stefan Hohmann
Jun 10, 2005·Microbiology and Molecular Biology Reviews : MMBR·David E Levin
Jun 8, 2001·Annual Review of Biochemistry·H G Dohlman, J W Thorner
Jan 19, 1999·Annual Review of Cell and Developmental Biology·A Schmidt, M N Hall
Jan 19, 1999·Annual Review of Microbiology·K Madden, M Snyder
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·P BalazM W Büchler
Dec 8, 2004·Genetics·Michael AyeSuzanne Sandmeyer
Apr 12, 2014·Annals of Botany·Timo Engelsdorf, Thorsten Hamann
Sep 8, 1997·The Journal of Cell Biology·J Philips, I Herskowitz
Jul 6, 2010·Peptides·Helena PortaAlejandra Bravo
Jun 16, 2007·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·David S Perlin
Jul 3, 2007·Biochimica Et Biophysica Acta·Raymond E Chen, Jeremy Thorner
Sep 21, 2013·Biochemical and Biophysical Research Communications·Miwha ChangCheol-Won Yun
Aug 10, 2016·Environmental Toxicology and Pharmacology·Ming JinXuetao Wei
Jul 27, 2007·Critical Reviews in Microbiology·Irina V Shemarova

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