Dynamics of active pharmaceutical ingredients loads in a Swiss university hospital wastewaters and prediction of the related environmental risk for the aquatic ecosystems

The Science of the Total Environment
Silwan DaoukSandrine Fleury-Souverain

Abstract

The wastewater contamination of a Swiss university hospital by active pharmaceutical ingredient (API) residues was evaluated with a three months monitoring campaign at the outlet of the main building. Flow-proportional samples were collected with an automatic refrigerated sampler and analyzed for 15 API, including antibiotics, analgesics, antiepileptic and anti-inflammatory drugs, by using a validated LC-MS/MS method. The metals Gd and Pt were also analyzed using ICP-MS. Measured concentrations were compared to the predicted ones calculated after the drug average consumption data obtained from the hospital pharmacy. The hospital contribution to the total urban load was calculated according to the consumption data obtained from city pharmacies. Lastly, the environmental hazard and risk quotients (RQ) related to the hospital fraction and the total urban consumption were calculated. Median concentrations of the 15 selected compounds were ranging from 0.04 to 675 μg/L, with a mean detection frequency of 84%. The ratio between predicted and measured environmental concentrations (PEC/MEC) has shown a good accuracy for 5 out of 15 compounds, revealing over- and under-estimations of the PEC model. Mean daily loads were ranging between ...Continue Reading

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Mar 25, 2016·Environmental Science & Technology·Keisuke KurodaChrista S McArdell
May 2, 2016·Environmental Pollution·Jérôme OryOusmane Traore
Jun 18, 2016·International Journal of Environmental Research and Public Health·La Thi Quynh LienCecilia Stålsby Lundborg
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Jun 28, 2018·Environmental Science and Pollution Research International·Meena K YadavChristopher P Saint
Nov 21, 2019·Environmental Science and Pollution Research International·Senar AydinArzu Ulvi
Jan 3, 2021·Environmental Science and Pollution Research International·Zeren Beril GönderGulsum Yilmaz
Jan 22, 2021·Environmental Monitoring and Assessment·Najmul Haque Barbhuiya, Asok Adak
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Jun 14, 2020·The Science of the Total Environment·Lydia NiemiStuart Gibb
Jun 28, 2019·Environmental Science & Technology·Akashdeep Singh OberoiHui Lu

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