Dynamics of bioactive follicle-stimulating hormone secretion in women with polycystic ovary syndrome: effects of estradiol and progesterone

Fertility and Sterility
V PadmanabhanI Z Beitins

Abstract

To determine the nature of bioactive FSH secretion in anovulatory women with polycystic ovary syndrome (PCOS) and its modulation by luteal levels of E2 and P. Interventional and observational study. Academic clinical research center. Five patients with PCOS. Treatment for 21 days with luteal levels of E2 and P. Serum levels of immunoreactive LH, immunoreactive FSH, bioreactive FSH, and the FSH isoform distribution pattern. Blood was sampled frequently and GnRH testing was done on day 0 (before treatment), days 10 and 20 (during treatment), and day 28 (7 days after treatment). Treatment with E2 and P suppressed circulating immunoreactive LH and immunoreactive FSH but not bioreactive FSH. Anovulatory women with PCOS showed a predominantly acidic pattern of FSH isoform distribution. Treatment with E2 and P shifted the distribution profile of FSH isoforms to the less acidic. After cessation of E2-P treatment, FSH reverted to its pretreatment pattern of distribution. Resumption of follicular growth after luteal replacement of E2 and P in anovulatory women with PCOS may be related to the reduction in the elevated LH/FSH ratio and accompanying changes in the FSH signal.

References

Oct 1, 1990·The Journal of Clinical Endocrinology and Metabolism·I Z BeitinsP C Sizonenko
Feb 15, 1984·American Journal of Obstetrics and Gynecology·R A LoboJ Campeau
Apr 1, 1984·The Journal of Clinical Endocrinology and Metabolism·D R MeldrumR J Chang
Oct 9, 1999·Journal of Molecular Endocrinology·P Damián-MatsumuraA Ulloa-Aguirre

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Citations

Jul 31, 2007·Reviews in Endocrine & Metabolic Disorders·Daniel A DumesicVasantha Padmanabhan
Aug 12, 2016·Nature Reviews. Disease Primers·Ricardo AzzizBulent O Yildiz
May 5, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Mone ZaidiLi Sun
Jun 24, 2021·Journal of the Endocrine Society·Leif WideKarin Eriksson

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