PMID: 15244846Jul 13, 2004Paper

Dynamics of biological molecules irradiated by short x-ray pulses

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Stefan P Hau-RiegeAbraham Szoke

Abstract

Very short and intense x-ray pulses can be used for diffraction imaging of single biological molecules. Inevitably, x-ray absorption initiates damage that degrades the molecule's image. This paper presents a continuum model of the physics that leads to damage when a small particle absorbs a large x-ray dose. The main processes are found to be ionization and Coulomb-force driven atomic motion. Trapping of electrons, Debye shielding, and nonuniform collisional ionization all have a significant effect on the overall damage kinetics.

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