Dynamics of Cux2 expression suggests that an early pool of SVZ precursors is fated to become upper cortical layer neurons

Cerebral Cortex
Céline ZimmerHarold Cremer

Abstract

Projection neurons destined for the cortical plate are generated sequentially from the proliferative ventricular and subventricular zones (VZ/SVZ) of the pallium. However, the respective contribution of both proliferative zones to the generation of cortical plate neurons is better established in humans and non-human primates than in rodents. We identified Cux2 as a new marker for murine cortical subpopulations and used it to provide new insights to the development of the mouse cortex. Cux2 is an orthologue of the Drosophila cut gene, which encodes a homeodomain protein involved in neuronal specification. During cortical development Cux2 identifies two subpopulations with different spatial origins, migratory behaviours and phenotypic characteristics: (i) a population of interneurons, which invades the pallium from the subpallium; and (ii) a neuronal population produced in the pallium around embryonic day 11.5, which divides in the SVZ and accumulates in the intermediate zone (IZ). Subsequently, Cux2 is a marker of upper cortical layers. Using different molecular markers and Pax6-deficient mice, we provide data that suggest a relationship between the early-determined Cux2-positive neuronal precursors in the SVZ/IZ and upper layer...Continue Reading

Citations

Nov 15, 2011·Experimental Brain Research·Hidenori TabataKazunori Nakajima
Jan 26, 2011·Molecular Psychiatry·R R KrishnanR S E Keefe
Sep 29, 2009·Nature Neuroscience·Ronald R Waclaw, Kenneth Campbell
Aug 8, 2006·Nature Neuroscience·Silvia CappelloMagdalena Götz
Nov 30, 2005·Nature Reviews. Molecular Cell Biology·Magdalena Götz, Wieland B Huttner
Oct 13, 2006·Nature Reviews. Neuroscience·Arnold KriegsteinVerónica Martínez-Cerdeño
May 22, 2007·Nature Reviews. Neuroscience·Colette Dehay, Henry Kennedy
May 22, 2007·Nature Reviews. Neuroscience·Bradley J MolyneauxJeffrey D Macklis
Oct 10, 2013·Nature Reviews. Neuroscience·L C GreigJ D Macklis
Jan 9, 2014·Nature Reviews. Neuroscience·Minoree Kohwi, Chris Q Doe
Mar 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nicole BüttnerTanja Vogel
Mar 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Zhifang XieWeiping J Zhang
Feb 6, 2008·Cerebral Cortex·Renata Batista-BritoGord Fishell
Aug 15, 2008·Cerebral Cortex·Frédéric CauseretMargareta Nikolic
Apr 7, 2009·Cerebral Cortex·Ashkan Javaherian, Arnold Kriegstein
Jan 12, 2012·Cerebral Cortex·Kerstin Hasenpusch-TheilThomas Theil
Sep 17, 2008·Genes & Development·Sebastian J ArnoldMatthias Groszer
Aug 11, 2012·Science·Santos J FrancoUlrich Müller
Jun 27, 2009·Annual Review of Neuroscience·Arnold Kriegstein, Arturo Alvarez-Buylla
Dec 14, 2007·Developmental Neuroscience·Adria PontiousRobert F Hevner
Oct 1, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lei WangElena B Pasquale
Nov 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wenfei KangJean M Hébert
Aug 6, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amaya MiquelajáureguiYangu Zhao
Oct 2, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bradley J MolyneauxJeffrey D Macklis
Oct 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·S YamamotoN Gotoh
Mar 13, 2014·Cellular and Molecular Life Sciences : CMLS·Tran Cong TuocAnastassia Stoykova
Jan 21, 2016·Journal of Biomedical Science·Amanjot Kaur RiarLenin Mahimainathan
Mar 8, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Chai MuhChyiKinichi Nakashima
Aug 13, 2015·The Journal of Comparative Neurology·Verónica Martínez-CerdeñoStephen C Noctor

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