Dynamics of epileptic seizures: evolution, spreading, and suppression

Journal of Theoretical Biology
J W KimP A Robinson

Abstract

Dynamical properties of epileptic seizures are investigated using a recent compact continuum model for electric activity of the brain. Large amplitude limit cycles resembling electroencephalograms during epilepsy emerge when the system loses linear stability. Seizures that are confined to an onset area, or spread synchronously to other areas via spatial coupling, are studied and argued to be associated with clinical partial and secondarily generalized seizures, respectively. Suppression of such seizures is also demonstrated, which implies potential for future clinical applications.

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Citations

Dec 19, 2012·Biological cybernetics·Zhen MaXueli Li
Dec 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Mark A KramerSydney S Cash
Feb 15, 2013·Journal of the Royal Society, Interface·Reuben O'DeaMarcus Kaiser
Apr 7, 2015·Journal of Neuroscience Methods·Fabrice WendlingViktor Jirsa
Jul 19, 2012·The European Journal of Neuroscience·Marc GoodfellowGerold Baier
Sep 26, 2015·Current Neurology and Neuroscience Reports·Dean R FreestoneMark J Cook
Jun 2, 2012·NeuroImage·J A Roberts, P A Robinson
Aug 15, 2014·PLoS Computational Biology·Yujiang WangGerold Baier
May 5, 2017·PLoS Computational Biology·Yujiang WangMarcus Kaiser
Jan 28, 2017·NeuroImage·Leonardo L GolloLuca Cocchi
Apr 2, 2017·Brain : a Journal of Neurology·Timothée ProixViktor K Jirsa
Feb 28, 2020·Journal of Neural Engineering·Arian AshourvanDanielle S Bassett
Oct 3, 2019·Physical Review. E·F DeebaP A Robinson
Oct 21, 2017·Scientific Reports·H Sohanian Haghighi, A H D Markazi
Sep 26, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·ShiNung ChingMark A Kramer

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