PMID: 22567973May 10, 2012Paper

Dynamics of hematologic parameters and of the erythrocyte deformability index at the juvenal period of rats and guinea pigs

Zhurnal evoliutsionnoĭ biokhimii i fiziologii
A V NovozhilovB A Feĭzullaev

Abstract

In experiments on Wistar rats and guinea pigs, dynamics of blood hematological parameters and of erythrocyte deformability index (DI) was studied from birth to the 3-month age. In rats, significant changes were revealed in the picture of blood for the first month of postnatal ontogenesis. The number of erythrocytes and leukocytes sharply increased, the number of reticulocytes decreased, their ratio in the degree of maturity was changed. The mean erythrocyte volume and their acidic resistance also decreased. Prior to the 4-week age, DI increased, which was accompanied by an increase in the hemoglobin hydration and flattening of the erythrocyte shape. Then ID decreased and erythrocytes acquired the more spherical shape. After the critical period of 3-4 weeks the studied parameters reached plateau. In guinea pigs, at this period of ontogenesis the hematologic parameters had sufficiently stable values, except for a DI decrease from birth to 1.5 months, then it rose without reaching the initial values. Like in the case with rats, DI had a close correlation with the erythrocyte parameter of shape (O min).

References

Jun 1, 1979·Australian Paediatric Journal·K L Harrison
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Sep 1, 1987·Neuroscience and Behavioral Physiology·V V Raevskii, K P Budko
Nov 29, 1974·Annals of the New York Academy of Sciences·H Kitchen, I Brett
Oct 27, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·L N Katyukhin Matskevich YuA

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Citations

Jul 12, 2017·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Wilson Jacob FilhoRomeu Rodrigues de Souza

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