Dynamics of intermittent viremia during highly active antiretroviral therapy in patients who initiate therapy during chronic versus acute and early human immunodeficiency virus type 1 infection

Journal of Virology
Michele Di MascioAlan S Perelson

Abstract

The meaning of viral blips in human immunodeficiency virus type 1 (HIV-1)-infected patients treated with seemingly effective highly active antiretroviral therapy (HAART) is still controversial and under investigation. Blips might represent low-level ongoing viral replication in the presence of drug or simply release of virions from the latent reservoir. Patients treated early during HIV-1 infection are more likely to have a lower total body viral burden, a homogenous viral population, and preserved HIV-1-specific immune responses. Consequently, viral blips may be less frequent in them than in patients treated during chronic infection. To test this hypothesis, we compared the occurrence of viral blips in 76 acutely infected patients (primary HIV infection [PHI] group) who started therapy within 6 months of the onset of symptoms with that in 47 patients who started HAART therapy during chronic infection (chronic HIV infection [CHI] group). Viral blip frequency was approximately twofold higher in CHI patients (0.122 +/- 0.12/viral load [VL] sample, mean +/- standard deviation) than in PHI patients (0.066 +/- 0.09/VL sample). However, in both groups, viral blip frequency did not increase with longer periods of observation. Also, no...Continue Reading

References

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Oct 29, 2003·Journal of Virology·Michele Di MascioAlan S Perelson

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Citations

May 25, 2010·Journal of Biopharmaceutical Statistics·Dean Follmann, Michael Fay
Mar 23, 2012·The Journal of Infectious Diseases·Babafemi Taiwo, Ronald J Bosch
May 15, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Laura E Jones, Alan S Perelson
Feb 9, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Babafemi TaiwoRonald J Bosch
May 23, 2009·HIV Medicine·Christophe CombescureUNKNOWN Swiss HIV Cohort Study
Sep 12, 2013·BMC Biology·Alan S Perelson, Ruy M Ribeiro
Jun 23, 2009·Journal of Theoretical Biology·Libin Rong, Alan S Perelson
Jul 23, 2016·IET Systems Biology·E Fabian CardozoRyan Zurakowski
Mar 10, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Matthew B FeldmanMary K Irvine
Sep 25, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Trevor A CrowellUNKNOWN RV254/SEARCH010 Study Group

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