Dynamics of intramolecular recognition: base-pairing in DNA/RNA near and far from equilibrium

The European Physical Journal. E, Soft Matter
Ralf Bundschuh, Ulrich Gerland

Abstract

The physics of the base-pairing interaction in DNA and RNA molecules plays a fundamental role in biology. Past experimental and theoretical research has led to a fairly complete and quantitative understanding of the equilibrium properties such as the different phases, the melting behavior, and the response to slow stretching. The non-equilibrium behavior is even richer than might be expected on the basis of thermodynamics. However, the non-equilibrium behavior is also far less understood. Here, we review different theoretical approaches to the study of base-pairing thermodynamics and kinetics, and illustrate the rich phenomenology with several examples that use these approaches.

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Citations

Nov 2, 2013·Journal of Mathematical Biology·Ralf Bundschuh
Jul 2, 2009·Journal of the American Chemical Society·Jens VölkerKenneth J Breslauer
Mar 16, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·V BaldazziR Monasson
Aug 27, 2009·The Journal of Physical Chemistry. B·Srividya MohanLoren Dean Williams

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