Dynamics of language reorganization after stroke

Brain : a Journal of Neurology
Dorothee SaurCornelius Weiller

Abstract

Previous functional imaging studies of chronic stroke patients with aphasia suggest that recovery of language occurs in a pre-existing, bilateral network with an upregulation of undamaged areas and a recruitment of perilesional tissue and homologue right language areas. The present study aimed at identifying the dynamics of reorganization in the language system by repeated functional MRI (fMRI) examinations with parallel language testing from the acute to the chronic stage. We examined 14 patients with aphasia due to an infarction of the left middle cerebral artery territory and an age-matched control group with an auditory comprehension task in an event-related design. Control subjects were scanned once, whereas patients were scanned repeatedly at three consecutive dates. All patients recovered clinically as shown by a set of aphasia tests. In the acute phase [mean: 1.8 days post-stroke (dps)], patients' group analysis showed little early activation of non-infarcted left-hemispheric language structures, while in the subacute phase (mean: 12.1 dps) a large increase of activation in the bilateral language network with peak activation in the right Broca-homologue (BHo) was observed. A direct comparison of both examinations reveal...Continue Reading

Citations

Nov 17, 2010·Der Nervenarzt·D Saur
Aug 16, 2012·Journal of Neurology·Tom TheysJohannes van Loon
Aug 17, 2011·Neuropsychology Review·Marcelo L BerthierAntonio Gutiérrez
Aug 16, 2011·Neuropsychology Review·Gottfried SchlaugCatherine Y Wan
Sep 1, 2008·Brain Imaging and Behavior·Jacquie KurlandRhonda B Friedman
Dec 17, 2008·Current Neurology and Neuroscience Reports·Mary L Dombovy
Oct 13, 2009·Current Neurology and Neuroscience Reports·Paula I MartinAlvaro Pascual-Leone
Sep 10, 2011·Current Neurology and Neuroscience Reports·Cécile Cauquil-MichonChristian Denier
Nov 26, 2011·Current Neurology and Neuroscience Reports·Constance Flamand-RozeChristian Denier
Oct 3, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Nuray Yozbatiran, Steven C Cramer
Mar 10, 2010·Nature Reviews. Neurology·Cathy J PriceAlex P Leff
Feb 8, 2011·Nature Reviews. Neurology·Marcelo L Berthier, Friedemann Pulvermüller
Jan 31, 2008·Journal of Speech, Language, and Hearing Research : JSLHR·Christy L LudlowChristine M Sapienza
Sep 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Gesa HartwigsenHartwig R Siebner
Sep 26, 2013·Proceedings of the National Academy of Sciences of the United States of America·Gesa HartwigsenHartwig R Siebner
Oct 25, 2008·Neuropsychological Rehabilitation·Luisa ZaunmüllerKlaus Willmes
Oct 21, 2011·Neuropsychological Rehabilitation·Stefano F Cappa
Jul 9, 2010·Developmental Neuropsychology·Chiara SpironelliAlessandro Angrilli
Dec 9, 2008·Brain : a Journal of Neurology·J MbwanaW D Gaillard
Jan 23, 2009·Brain : a Journal of Neurology·Robin J SchaferLaura R Ment
Nov 12, 2009·Brain : a Journal of Neurology·Jane E WarrenRichard J S Wise
Mar 20, 2010·Brain : a Journal of Neurology·Dorothee SaurStefan Klöppel
Apr 1, 2010·Brain : a Journal of Neurology·Liang WangChaozhe Zhu
Sep 10, 2010·Brain : a Journal of Neurology·Mahinda YogarajahJohn S Duncan
Mar 19, 2011·Brain : a Journal of Neurology·Christian Grefkes, Gereon R Fink
Apr 13, 2011·Brain : a Journal of Neurology·Steven C CramerSophia Vinogradov
Sep 29, 2011·Brain : a Journal of Neurology·Roza M UmarovaCornelius Weiller
Sep 9, 2011·Brain : a Journal of Neurology·Argye E Hillis
Sep 29, 2011·Brain : a Journal of Neurology·Benjamin StahlStefan Geyer
Feb 5, 2013·Brain : a Journal of Neurology·Dorothee KümmererDorothee Saur
Nov 8, 2008·Current Opinion in Neurology·Marie-Hélène Milot, Steven C Cramer
Mar 20, 2010·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Margaret A NaeserAlvaro Pascual-Leone
May 11, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C Flamand-RozeC Denier
Nov 28, 2008·Annual Review of Psychology·Denise C Park, Patricia Reuter-Lorenz
May 6, 2009·Journal of Cognitive Neuroscience·Whitney Anne Postman-CaucheteuxAllen R Braun
Feb 5, 2009·Neurorehabilitation and Neural Repair·UNKNOWN Cumberland Consensus Working GroupSteven Wolf
Sep 22, 2009·Neurorehabilitation and Neural Repair·Michael A Dimyan, Leonardo G Cohen
Aug 2, 2011·Neurorehabilitation and Neural Repair·Alex R CarterMaurizio Corbetta
Sep 24, 2009·BMC Neuroscience·Ricarda MenkeCaterina Breitenstein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.