Dynamics of neutrophil migration in lymph nodes during infection.

Immunity
Tatyana ChtanovaEllen A Robey

Abstract

Although the signals that control neutrophil migration from the blood to sites of infection have been well characterized, little is known about their migration patterns within lymph nodes or the strategies that neutrophils use to find their local sites of action. To address these questions, we used two-photon scanning-laser microscopy to examine neutrophil migration in intact lymph nodes during infection with an intracellular parasite, Toxoplasma gondii. We found that neutrophils formed both small, transient and large, persistent swarms via a coordinated migration pattern. We provided evidence that cooperative action of neutrophils and parasite egress from host cells could trigger swarm formation. Neutrophil swarm formation coincided in space and time with the removal of macrophages that line the subcapsular sinus of the lymph node. Our data provide insights into the cellular mechanisms underlying neutrophil swarming and suggest new roles for neutrophils in shaping immune responses.

References

Aug 1, 1991·Parasitology·M Nakao, E Konishi
Aug 1, 1991·Parasitology·M Nakao, E Konishi
Sep 7, 2000·Microbiology and Molecular Biology Reviews : MMBR·M W Black, J C Boothroyd
Jan 4, 2001·Immunological Reviews·P ScapiniM A Cassatella
Feb 26, 2003·Cell·Paul W KriebelCarole A Parent
Mar 6, 2004·Science·Volker BrinkmannArturo Zychlinsky
Mar 9, 2004·International Journal for Parasitology·Eric Y DenkersSoumaya Bennouna
Apr 30, 2005·Science·Felix YarovinskyAlan Sher
Feb 25, 2006·Nature Reviews. Immunology·Carl Nathan
Jun 27, 2006·Nature Reviews. Immunology·Ronald N GermainMichel C Nussenzweig
Jul 13, 2006·Blood·Belkys A MalettoMaría C Pistoresi-Palencia
Dec 13, 2006·Trends in Microbiology·Rui Appelberg
Jun 15, 2007·Blood·Céline BeauvillainPascale Jeannin
Jan 5, 2008·Annual Review of Immunology·Michael D Cahalan, Ian Parker
Jan 15, 2008·Nature Immunology·Heather D HickmanJonathan W Yewdell
Jan 24, 2008·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·B H ZinselmeyerM J Miller

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Citations

Feb 21, 2013·Cellular and Molecular Life Sciences : CMLS·Janesh PillayLeo Koenderman
Sep 8, 2012·Seminars in Immunopathology·Christopher D DupontChristopher A Hunter
Nov 7, 2008·Histochemistry and Cell Biology·Ben RoedigerWolfgang Weninger
Mar 13, 2012·Immunologic Research·Jackson LiangYao Li, Lai Guan Ng
Aug 1, 2012·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Jasmin HerzDorian B McGavern
Jun 10, 2010·Immunology and Cell Biology·Jason G Cyster
Jun 8, 2011·Immunology and Cell Biology·Michael de VeerEls N T Meeusen
Nov 21, 2012·Immunology and Cell Biology·Harriet B TaylorMargaret J Dallman
Mar 6, 2013·Immunology and Cell Biology·Rohit Jain, Wolfgang Weninger
May 28, 2013·Nature·Tim LämmermannRonald N Germain
Oct 21, 2010·Nature Immunology·Jason G Cyster
Apr 17, 2010·Nature Reviews. Immunology·Janine L Coombes, Ellen A Robey
Jul 26, 2011·Nature Reviews. Immunology·Alberto MantovaniSébastien Jaillon
Feb 9, 2013·Integrative Biology : Quantitative Biosciences From Nano to Macro·Yana Wang, Darrell J Irvine
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Stephanie L OsbornAstar Winoto
Oct 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Daniel KreiselMark J Miller
May 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Janine L CoombesEllen A Robey
Jan 23, 2013·The Journal of Experimental Medicine·Chiao-Wen Yang, Emil R Unanue
Jun 30, 2012·Science·Ronald N GermainMichael D Cahalan
Apr 11, 2012·Journal of Innate Immunity·Elizabeth E Gray, Jason G Cyster
Mar 26, 2011·Thrombosis and Haemostasis·R T A MegensO Soehnlein
May 5, 2010·The Journal of Clinical Investigation·Emma H WilsonChristopher A Hunter
Nov 6, 2010·Blood·Céline BeauvillainPascale Jeannin
Jul 21, 2010·PLoS Neglected Tropical Diseases·Adriana M C CanavaciRick L Tarleton
Aug 14, 2010·PLoS Neglected Tropical Diseases·Lisa SharlingBoris Striepen
Mar 7, 2012·PloS One·Zachary P WeinerIan J Glomski
Sep 26, 2013·PloS One·Silke MüllerWaldemar Kolanus
Apr 2, 2011·PLoS Pathogens·Janelle C WaiteMichael L Dustin

❮ Previous
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