Dynamics of nuclear receptor target gene regulation.

Chromosoma
Carsten Carlberg, Sabine Seuter

Abstract

Ligand-regulated nuclear receptors, such as estrogen receptors, glucocorticoid receptor, vitamin D receptor, and peroxisome proliferator-activated receptors, belong to the most widely studied and best understood transcription factors. Therefore, the dynamic nature of transcriptional regulation was observed first with different members of the nuclear receptor superfamily, but is now also extended to other transcription factors, such as nuclear factor κB. Dynamic and in part cyclical processes were observed on the level of translocation into the nucleus, association with genomic binding sites, exchange of co-regulators and chromatin modifiers, occurrence of chromatin marks, and activities of RNA polymerase II resulting in mRNA synthesis. In this review, we summarize recent findings on the dynamic regulation of nuclear receptor target genes in the chromatin context.

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Citations

Jan 13, 2012·Cancer Chemotherapy and Pharmacology·Yong-sheng YuGuo-qing Zang
Sep 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Eugine LeeSusan K Logan
Sep 13, 2012·Journal of Biochemistry·Tomofumi FujinoMakio Hayakawa
May 3, 2014·PloS One·Pauli TuoresmäkiCarsten Carlberg
May 24, 2014·The Journal of Nutritional Biochemistry·Julia WilfingerCarsten Carlberg
Jan 31, 2015·Molecular Medicine Reports·Long DingWeibin Xia
Apr 1, 2011·Clinical Epigenetics·Heidrun Karlic, Franz Varga
Oct 7, 2015·Nature Reviews. Endocrinology·Wilson SavinoMireille Dardenne
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Dec 12, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Sabine SeuterCarsten Carlberg
Dec 12, 2012·The Journal of Pediatrics·Haidong ZhuYanbin Dong
Feb 20, 2019·Endocrine-related Cancer·Peder Rustøen Braadland, Alfonso Urbanucci
Jul 17, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shivaprakash J MuttKarl-Heinz Herzig
Jun 3, 2015·World Journal of Gastroenterology : WJG·Olga A SukochevaDavid I Watson
Mar 8, 2019·Endocrine-related Cancer·Peder Rustøen Braadland, Alfonso Urbanucci
Oct 19, 2019·International Journal of Molecular Sciences·Smriti Murali Krishna
May 24, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Saleha AnwarMd Imtaiyaz Hassan

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Methods Mentioned

BETA
PCR
acetylation
immunoprecipitation
ChIP
fluorescence recovery after photobleaching
nuclear translocation

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