Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes - Type 1 Diabetes Prediction and Prevention Study (DIPP)

Scientific Reports
Santosh LamichhaneMatej Oresic

Abstract

Type 1 diabetes (T1D) is one of the most prevalent autoimmune diseases among children in Western countries. Earlier metabolomics studies suggest that T1D is preceded by dysregulation of lipid metabolism. Here we used a lipidomics approach to analyze molecular lipids in a prospective series of 428 plasma samples from 40 children who progressed to T1D (PT1D), 40 children who developed at least a single islet autoantibody but did not progress to T1D during the follow-up (P1Ab) and 40 matched controls (CTR). Sphingomyelins were found to be persistently downregulated in PT1D when compared to the P1Ab and CTR groups. Triacylglycerols and phosphatidylcholines were mainly downregulated in PT1D as compared to P1Ab at the age of 3 months. Our study suggests that distinct lipidomic signatures characterize children who progressed to islet autoimmunity or overt T1D, which may be helpful in the identification of at-risk children before the initiation of autoimmunity.

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Citations

Jan 24, 2019·Biomolecules·Santosh LamichhaneMatej Oresic
Aug 25, 2019·Diabetologia·Santosh LamichhaneMatej Orešič
Oct 17, 2019·Scientific Reports·Randi K JohnsonUNKNOWN TEDDY Study Group
Jun 17, 2020·PloS One·Naba Al-SariCristina Legido-Quigley
Jul 8, 2019·Analytical and Bioanalytical Chemistry·Ngoc VuQibin Zhang
Dec 6, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Marina Amaral AlvesMatej Orešič
Jun 1, 2021·Frontiers in Immunology·Renata Auricchio, Riccardo Troncone
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Feb 4, 2022·Current Diabetes Reports·Daniel Gonzalez Izundegui, Matthew Nayor

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Methods Mentioned

BETA
PCA

Software Mentioned

MetaboLights
PLS
mat
MassHunter
MATLAB
GraphPad
MZmine
GraphPad Prism
PLS Toolbox
DA

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