Dynamics of polymer translocation through kinked nanopores

The Journal of Chemical Physics
Junfang WangKaifu Luo

Abstract

Polymer translocation through nanopore has potential technological applications for DNA sequencing, where one challenge problem is to slow down translocation speed. Inspired by experimental findings that kinked nanopores exhibit a large reduction in translocation velocity compared with their straight counterparts, we investigate the dynamics of polymer translocation through kinked nanopores in two dimensions under an applied external field. With increasing the tortuosity of an array of nanopores, our analytical results show that the translocation probability decreases. Langevin dynamics simulation results support this prediction and further indicate that with increasing the tortuosity, translocation time shows a slow increase followed by a rapid increase after a critical tortuosity. This behavior demonstrates that kinked nanopores can effectively reduce translocation speed. These results are interpreted by the roles of the tortuosity for decreasing the effective nanopore diameter, increasing effective nanopore length, and greatly increasing the DNA-pore friction.

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Citations

Dec 24, 2015·The Journal of Chemical Physics·Chao WangMeng-Bo Luo
Dec 1, 2019·Scientific Reports·Mohammadreza Niknam Hamidabad, Rouhollah Haji Abdolvahab
May 3, 2019·The Journal of Chemical Physics·Chao WangMeng-Bo Luo
Oct 2, 2019·The Journal of Physical Chemistry. B·Karthik Nagarajan, Shing Bor Chen

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