Dynamics of porcine circovirus type 2 infection in a herd of pigs with postweaning multisystemic wasting syndrome

American Journal of Veterinary Research
Gabriela M Rodríguez-ArriojaMariano Domingo

Abstract

To determine the pattern of infection for porcine circovirus type 2 (PCV2) in a herd of pigs with postweaning multisystemic wasting syndrome (PMWS). 29 sows and 250 pigs. Blood samples were collected from all 3-, 7-, and 12-week old pigs and 59 pigs at 28 weeks of age. Pigs that died during the study were necropsied. Porcine parvovirus and PCV2 antibodies were assayed. A polymerase chain reaction (PCR) was used to detect PCV2 genome in serum of selected pigs. The PMWS started when pigs were 8 weeks old, with a prevalence of 30% in 8- to 10-week-old pigs. Eighty-three pigs died during the period between 3 and 12 weeks of age. Microscopic lesions consistent with PMWS were observed, and PCV2 nucleic acid was detected (50 of 68 pigs). Antibodies to PCV2 decreased from 3 to 7 weeks of age, increased at 12 weeks of age, and were maintained until 28 weeks of age. One sow had a positive result for PCR of serum. Nine, 37 and 8 pigs had PCV2 genome in serum obtained at 7, 12, and 28 weeks of age, respectively. Infection with PCV2 coincided with severe clinical signs; however, infected 28-week-old pigs did not have evidence of disease. Immunity declined over time in young pigs. A long duration of PCV2 viremia was apparent in a high percen...Continue Reading

References

Feb 26, 2000·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·G M Allan, J A Ellis
Feb 26, 2000·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·J A EllisF McNeilly
Jul 26, 2000·The Veterinary Record·G M Rodríguez-ArriojaM Domingo

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Citations

Apr 6, 2006·Animal Health Research Reviews·Joaquim SegalésMariano Domingo
Sep 29, 2009·Journal of Veterinary Internal Medicine·J GillespieV Buechner-Maxwell
Mar 18, 2008·Journal of the American Veterinary Medical Association·Kyle P HorlenRaymond R R Rowland
Oct 29, 2002·The Veterinary Quarterly·J Segalés, M Domingo
Dec 20, 2011·Virus Research·Nicolas RoseAndré Jestin
May 11, 2010·Veterinary Immunology and Immunopathology·T KekarainenG M Allan
Mar 10, 2010·The Veterinary Journal·Llorenç Grau-RomaJoaquim Segalés
Dec 7, 2007·Virus Research·Richard HesseRaymond R R Rowland
Mar 21, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Tomáš CsankMikuláš Levkut
Apr 19, 2015·Veterinary Research·Hanna C KoinigArmin Saalmüller
Jul 23, 2013·Veterinary Microbiology·Cheryl M T DvorakMichael P Murtaugh
Jun 14, 2005·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Steven KrakowkaGordon Allan
Jan 19, 2010·Veterinary Pathology·I M LangohrR M Pogranichniy
Jun 10, 2004·The Journal of Veterinary Medical Science·Chun WangShiow-Suey Lai
Nov 18, 2014·Expert Review of Vaccines·Joaquim Segalés
Sep 3, 2008·Animal Health Research Reviews·Sheela Ramamoorthy, Xiang-Jin Meng
Nov 19, 2015·Porcine Health Management·Tuija Kekarainen, Joaquim Segalés

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