PMID: 9183742Jun 5, 1997Paper

Dynamics of process formation during differentiation of tectal neurons in embryonic zebrafish

Journal of Neurobiology
R J Kaethner, C A Stuermer

Abstract

Neurons acquire their distinct shapes after passing through many transitional stages in early development. To reveal the dynamics and spatiotemporal sequence of process formation in situ, the growth of neurons in the optic tectum of live zebrafish embryos (54 to > 100 h old) was monitored using time-lapse videorecordings. Neurons were labeled by injecting the fluorescent vital dye DiO into the cell-rich layer of the developing tectum in 50- to 70-h-old embryos. In phase 1, tectal neurons possess an apical "primary process" which reaches to the ventral aspect of the tectal neuropil. The primary process produces at its tip short transitory branches, some with growth cones, over a period of roughly 6 h. One of the growth cones then elongates rapidly and grows toward the caudal tectum via a route characteristic of efferent axons. After retraction of excess branches and growth cones, branching activity resumes at the tip of the primary process to form the dendritic tree (phase 2). The dendritic tree develops in the tectal neuropil through emission and retraction of many branches during a period of > 20 h (our longest continuous time-lapse movie). The tectal territory "explored" in this way is larger than the area finally covered by ...Continue Reading

Citations

Dec 10, 2015·Nano Letters·Kyungtae KangInsung S Choi
May 16, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Kelly Juliana SeibtCarla Denise Bonan
Feb 11, 2011·Developmental Neurobiology·Nikolas Nikolaou, Martin P Meyer
Jul 16, 2011·Developmental Neurobiology·Gaia Tavosanis
Nov 27, 2015·Neuron·Nikolas Nikolaou, Martin P Meyer
Sep 5, 2002·Nature Reviews. Neuroscience·Jorge Santos da Silva, Carlos G Dotti

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