Mar 1, 1975

Dynamics of production and various properties of interferon-like inhibitors formed under the influence of AET and cystaphos in vivo and in cell cultures

Voprosy virusologii
A G Khaitovich, E A L'vovskii


Interferon-like virus inhibitors appeared in the blood serum of animals and in the culture fluid 15 min.--1 hour and 4-6 hours after administration of AET (S, beta-amino-ethylisotiuronium) and cystaphos (monosodium salt of beta-aminoethylthiophosphorus acid). These inhibitors showed species-specificity, were inactivated by trypsin and by heating at 37 degrees C for 2 hours and at 56 degrees C for 1 hour, did not sediment at 100,000 g. It is assumed that these are two different inhibitors of which the one forming the early peak pre-exists in the cell. It is probably associated with cell membranes and is released as a result of chemical effect of aminothyols. The late peak of inhibitor is synthesized de novo as inducated by its sensitivity to the effect of puromycin and cycloheximide.

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Mentioned in this Paper

Cell Culture Techniques
Human leukocyte interferon
Puromycin Dihydrochloride
Organothiophosphorus Compounds
Interferon Inducers

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