PMID: 8989390Oct 1, 1995Paper

Dynamics of sensory afferent synaptic transmission in aortic baroreceptor regions on nucleus tractus solitarius

Journal of Neurophysiology
M C Andresen, M Yang

Abstract

1. Synaptic responses of medial nucleus tractus solitarius (mNTS) neurons to solitary tract (ST) activation were studied in a horizontal brain slice preparation of the rat medulla. Slices included sections of ST sufficiently long that the ST could be electrically activated several millimeters from the recording site of cell bodies in mNTS. 2. Three types of synaptic events were evoked in response to ST stimulation: simple excitatory postsynaptic potentials (EPSPs), simple inhibitory postsynaptic potentials (IPSPs), and complex EPSP-IPSP sequences. Simple EPSPs had substantially shorter latencies than IPSPs (3.39 +/- 0.65 ms, mean +/- SE, n = 42, vs. 5.86 +/- 0.71 ms, n = 6, respectively). 3. EPSP amplitude increased linearly with increasing hyperpolarization, with an extrapolated reversal potential near 0 mV. 4. EPSPs were maximal at < 0.5 Hz of sustained, constant-frequency ST stimulation (n = 14). EPSP amplitude declined to an average of 57.5% of control at 10 Hz after 2 s of sustained stimulation. With 1 min of sustained, 100-Hz stimulation, EPSP amplitude declined to near zero. 5. With stimuli intermittently delivered as 100-ms bursts every 300 ms, generally comparable average EPSPs were evoked during constant and burst pat...Continue Reading

Citations

Mar 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·T KawadaK Sunagawa
Apr 6, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M C AndresenY-H Jin
Sep 5, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Helio C SalgadoRubens Fazan
Oct 19, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael C AndresenJessica A Fawley
Nov 2, 2012·Journal of Neurophysiology·Stuart J McDougall, Michael C Andresen
Aug 4, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jessica A Fawley, Michael C Andresen
Jul 19, 2001·Annals of the New York Academy of Sciences·M HayJ Pamidimukkala
Jan 18, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karen L BarnesMichael C Andresen
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J Pamidimukkala, M Hay
Feb 15, 2008·Journal of Neurophysiology·Timothy W BaileyMichael C Andresen
Sep 16, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Michael C Andresen, James H Peters
Sep 5, 2012·The Journal of Physiology·Stuart J McDougall, Michael C Andresen
Oct 12, 1999·The American Journal of Physiology·C Y ChenA C Bonham
Jul 19, 2001·Annals of the New York Academy of Sciences·M C AndresenT W Bailey
Jul 31, 1998·The American Journal of Physiology·M Hay, E M Hasser
Jul 2, 2010·Experimental Physiology·Jasenka Zubcevic, Jeffrey T Potts
Jul 8, 2011·Journal of Neurophysiology·Jessica A FawleyMichael C Andresen
Feb 9, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Z LiuA C Bonham
May 16, 2001·Journal of Neurophysiology·M W Doyle, M C Andresen

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