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Dynamics of T cell activation mediated by eIF3 interactions with T cell receptor mRNAs

bioRxiv

Dec 21, 2019

Dasmanthie De SilvaJamie H. D. Cate

Abstract

Activation of T cells requires a global surge in cellular protein synthesis, which is accompanied by a large increase in translation initiation[1][1]–[4][2]. A central component of the translation initiation machinery–the multi-subunit eukaryotic initiation factor 3 (eIF3)–is rapidly tu...read more

Mentioned in this Paper

Tissue Engineering
Contact With Machinery
Translation Initiation
Fluorescent in Situ Hybridization
T-cell Receptor Activity
Antigen T Cell Receptor, beta Chain
Transcriptome
T-Cell Receptor
T-Cell Receptors alpha-Chain
Immunotherapy
28
Paper Details
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Dynamics of T cell activation mediated by eIF3 interactions with T cell receptor mRNAs

bioRxiv

Dec 21, 2019

Dasmanthie De SilvaJamie H. D. Cate

PMID: 990885558

DOI: 10.1101/2019.12.20.885558

Abstract

Activation of T cells requires a global surge in cellular protein synthesis, which is accompanied by a large increase in translation initiation[1][1]–[4][2]. A central component of the translation initiation machinery–the multi-subunit eukaryotic initiation factor 3 (eIF3)–is rapidly tu...read more

Mentioned in this Paper

Tissue Engineering
Contact With Machinery
Translation Initiation
Fluorescent in Situ Hybridization
T-cell Receptor Activity
Antigen T Cell Receptor, beta Chain
Transcriptome
T-Cell Receptor
T-Cell Receptors alpha-Chain
Immunotherapy
28

Similar Papers Found In These Feeds

T cell Activation

T cell activation is a crucial checkpoint in adaptive immunity, and this activation depends on the binding parameters that govern the interactions between T cell receptors and peptide-MHC complexes. Here is the latest research.

Tissue Engineering

Tissue engineering is an interdisciplinary field that aims to create, repair, and/or replace tissues and organs by using biomaterial scaffolds, growth factors, stem cells, and genetic engineering. Discover the latest research on tissue engineering here.

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Architecture of human translation initiation factor 3

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