Abstract
To analyze the dynamic changes in Th1, Th2, Tc1, and Tc2 of HIV/AIDS patients during the first year of highly active antiretroviral therapy (HAART) and to explore their relationship with oral and systemic opportunistic infections, a cohort study was carried out among HIV/AIDS patients in Guangxi, China. Ninety HIV/AIDS patients and 30 healthy controls (HC) were included. The enrolled HIV/AIDS patients were examined at baseline and after 3, 6, and 12 months of HAART. On each visit, oral and systemic opportunistic infections were recorded, oral Candida load and plasma viral load (VL) were counted, differential T-cell counts and flow cytometric analysis of T-cell subsets were performed. During the first year of HAART, the total number of opportunistic infections decreased steadily with the change in oral candidiasis (OC) most representatively. A significant Th1→Th2 switch (Th1/Th2 ratio 0.23 ± 0.12, HC 1.45 ± 0.38) and slight Tc1→Tc2 shift (Tc1/Tc2 ratio 0.93 ± 0.29, HC 1.13 ± 0.33) were found at baseline, and both received slow mitigation after HAART. LgCFU and clinical OC were correlated positively with both LgVL and clinical stage (P < 0.05) at baseline. LgCFU was also correlated positively with clinical stage at all four time ...Continue Reading
References
Dec 1, 1994·Immunology Today·M Clerici, G M Shearer
Aug 1, 1994·The Journal of Experimental Medicine·E MaggiS Romagnani
Mar 1, 1993·Immunology Today·M Clerici, G M Shearer
Mar 1, 1993·Radiology·L S SteinbachM J Pais
Dec 12, 1996·Nature·A S Fauci
Jan 15, 1998·Parasite Immunology·I EmeryC Leclerc
Feb 10, 1998·AIDS·R E ChaissonR D Moore
Nov 21, 1998·Journal of Leukocyte Biology·J WangK Matsushima
Mar 10, 2001·Cell Biology International·U BreytenbachP Bouic
Mar 23, 2001·Infection·J R BognerF D Goebel
Mar 19, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·J CampoA Bascones
Feb 7, 2003·Current Medicinal Chemistry·L BelmonteB H Ruibal-Ares
Jan 24, 2004·Virus Genes·Yechiel Becker
Apr 20, 2004·Oral Diseases·D KerdponV Robison
Apr 20, 2004·AIDS·Thomas O KleenMagdalena Tary-Lehmann
Oct 16, 2004·Expert Review of Anti-infective Therapy·Patrick Willemot, Marina B Klein
Jun 14, 2005·FEMS Immunology and Medical Microbiology·H Handan AkbulutMehmet Ozden
Feb 17, 2006·Journal of Medical Virology·Sardar SindhuJosé Menezes
Mar 22, 2006·AIDS·Rebecca SutherlandLucy Dorrell
Aug 1, 2008·Clinical Oral Investigations·Gaurav SharmaArchna Nagpal
May 27, 2010·BMC Infectious Diseases·Julia PohlingMichael D Grant
Jan 5, 2011·Immunological Reviews·George Makedonas, Michael R Betts
Sep 17, 2011·Human Immunology·Naveed GulzarKaren F T Copeland
Nov 19, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chad J AchenbachMari M Kitahata
Jan 4, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·J HanS Lian
Feb 11, 2012·Journal of the International Association of Providers of AIDS Care·Smita KamtanePrashant Suvarna
Jul 17, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Claudia J DembekAntonio Cosma
Sep 11, 2012·BMJ Case Reports·John-Paul Tantiongco
Feb 23, 2013·BMJ Case Reports·Peter Ng
Aug 13, 2013·Vaccine·Danushka K WijesundaraCharani Ranasinghe
Jan 1, 2014·BMJ Case Reports·Suheil Artul